CD163 monoclonal antibody (AGIM0091)
- SKU:
- AGIM0091
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- GHI/61
- Conjugation:
- Unconjugated
- Applications:
- FC
Description
system_update_altDatasheet
| Product Name: | CD163 monoclonal antibody |
| Product Code: | AGIM0091 |
| Size: | 100 µg in 100 µL |
| Reactivity: | Human |
| Clone: | GHI/61 |
| Applications: | Flow Cytometry |
| Conjugate: | Unconjugated |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 2 °- 8°C. Do not freeze! |
| Uniprot: | Q86VB7 |
| Background: | CD163, also known as M130, is a member of the scavenger receptor family, accounting for the clearance of hemoglobin-haptoglobin complexes during limited hemolysis, which protects the body, in particular the kidneys, against heme-mediated oxidative damages. It does not have measurable affinity for noncomplexed hemoglobin or haptoglobin. Immunomodulatory role of CD163 has been postulated. CD163 is expressed by cells of the monocyte-macrophage lineage and its extracellular part also circulates in plasma as a soluble protein, especially during sepsis and other conditions affecting macrophage activity, when its level may raise manyfold. |
| NCBI Summary: | The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q86VB7 |
| NCBI GenInfo Identifier: | 313104083 |
| NCBI Gene ID: | 9332 |
| NCBI Accession: | |
| UniProt Related Accession: | Q86VB7 |
| Molecular Weight: | |
| NCBI Full Name: | Scavenger receptor cysteine-rich type 1 protein M130 |
| NCBI Synonym Full Names: | CD163 molecule |
| NCBI Official Symbol: | CD163 |
| NCBI Official Synonym Symbols: | M130; MM130; SCARI1 |
| NCBI Protein Information: | scavenger receptor cysteine-rich type 1 protein M130 |
| UniProt Protein Name: | |
| Protein Family: | Scavenger receptor cysteine-rich type 1 protein |
| UniProt Gene Name: |
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