Cd163 Antibody (PACO35870)
- SKU:
- PACO35870
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Cd163 Antibody (PACO35870) |
| Antibody SKU: | PACO35870 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Scavenger receptor cysteine-rich type 1 protein M130 protein (86-365AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: HL60 whole cell lysate. All lanes: Cd163 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 121, 126 kDa. Observed band size: 121 kDa. |
| Background: | Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity). |
| Synonyms: | Scavenger receptor cysteine-rich type 1 protein M130 (CD antigen CD163) [Cleaved into: Soluble CD163 (sCD163)], Cd163, M130 |
| UniProt Protein Function: | CD163: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Cellular Component: membrane; extracellular region; plasma membrane; integral to membrane Molecular Function:scavenger receptor activity Biological Process: receptor-mediated endocytosis; acute-phase response; inflammatory response |
| UniProt Code: | Q2VLH6 |
| NCBI GenInfo Identifier: | 341940294 |
| NCBI Gene ID: | 93671 |
| NCBI Accession: | Q2VLH6.2 |
| UniProt Secondary Accession: | Q2VLH6,Q2VLH5, Q99MX8, A6H691, |
| UniProt Related Accession: | Q2VLH6 |
| Molecular Weight: | 125,292 Da |
| NCBI Full Name: | Scavenger receptor cysteine-rich type 1 protein M130 |
| NCBI Synonym Full Names: | CD163 antigen |
| NCBI Official Symbol: | Cd163 |
| NCBI Official Synonym Symbols: | CD163v2; CD163v3 |
| NCBI Protein Information: | scavenger receptor cysteine-rich type 1 protein M130 |
| UniProt Protein Name: | Scavenger receptor cysteine-rich type 1 protein M130 |
| UniProt Synonym Protein Names: | CD_antigen: CD163Cleaved into the following chain:Soluble CD163; sCD163 |
| Protein Family: | Scavenger receptor cysteine-rich type 1 protein |
| UniProt Gene Name: | Cd163 |
| UniProt Entry Name: | C163A_MOUSE |
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