CD11c (no azide) monoclonal antibody (AGIM0161)
- SKU:
- AGIM0161
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- BU15
- Conjugation:
- Unconjugated
- Applications:
- FC
Description
system_update_altDatasheet
| Product Name: | CD11c (no azide) monoclonal antibody |
| Product Code: | AGIM0161 |
| Size: | 100 µg in 100 µL |
| Reactivity: | Human |
| Clone: | BU15 |
| Applications: | Flow Cytometry |
| Conjugate: | Unconjugated |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. |
| Uniprot: | P20702 |
| Background: | CD11c (p150, ?±X integrin subunit) forms complex with CD18 (??2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other ??2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b. |
| UniProt Protein Function: | ITGAX: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Belongs to the integrin alpha chain family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cell surface; membrane; plasma membrane Molecular Function:protein binding; receptor activity Biological Process: cell adhesion; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; leukocyte migration; organ morphogenesis Disease: Systemic Lupus Erythematosus |
| NCBI Summary: | This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
| UniProt Code: | P20702 |
| NCBI GenInfo Identifier: | 146345441 |
| NCBI Gene ID: | 3687 |
| NCBI Accession: | P20702.3 |
| UniProt Secondary Accession: | P20702,Q8IVA6, |
| UniProt Related Accession: | P20702 |
| Molecular Weight: | 127,829 Da |
| NCBI Full Name: | Integrin alpha-X |
| NCBI Synonym Full Names: | integrin subunit alpha X |
| NCBI Official Symbol: | ITGAX |
| NCBI Official Synonym Symbols: | CD11C; SLEB6 |
| NCBI Protein Information: | integrin alpha-X |
| UniProt Protein Name: | Integrin alpha-X |
| UniProt Synonym Protein Names: | CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD_antigen: CD11c |
| UniProt Gene Name: | ITGAX |
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