CD11a Monoclonal Antibody (CAB24887)
- SKU:
- CAB24887
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG1
- Applications:
- WB
- Applications:
- FC
Description
| Product Name: | CD11a Monoclonal Antibody |
| Product Code: | CAB24887 |
| Reactivity: | Human |
| Applications: | Western blotting, Flow Cytometry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG1 |
| Clone No: | ARC62732 |
| Reactivity: | Human |
| Tested Applications: | WB, FC |
| Key Applications: | Western blotting, Flow Cytometry |
| Recommended Dilution: | WB 1:500-1:1000, FC 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | MOLT-4 |
| Cellular Location: | Membrane, single-pass type I membrane protein |
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-340 of human CD11a (NP_002200.2). |
| Sequence: | YNLDV RGARS FSPPR AGRHF GYRVL QVGNG VIVGA PGEGN STGSL YQCQS GTGHC LPVTL RGSNY TSKYL GMTLA TDPTD GSILA CDPGL SRTCD QNTYL SGLCY LFRQN LQGPM LQGRP GFQEC IKGNV DLVFL FDGSM SLQPD EFQKI LDFMK DVMKK LSNTS YQFAA VQFST SYKTE FDFSD YVKRK DPDAL LKHVK HMLLL TNTFG AINYV ATEVF REELG ARPDA TKVLI IITDG EATDS GNIDA AKDII RYIIG IGKHF QTKES QETLH KFASK PASEF VKILD TFEKL KDLFT ELQKK IYVIE GTSKQ |
| Synonyms: | CD11A, LFA-1, LFA1A |
| Calculated MW: | 118kDa/129kDa/134kDa |
| Observed MW: | 180kDa |
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