CCR2 Antibody (PACO02278)
- SKU:
- PACO02278
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CCR2 Antibody |
| Antibody SKU: | PACO02278 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IF:1:200-1:1000 |
| Species Reactivity: | Mouse, Rat |
| Immunogen: | synthesized peptide derived from the C-terminal region of human CKR-2. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | CCR2; CMKBR2; C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; Monocyte chemoattractant protein 1 receptor; MCP-1-R; CD antigen CD192 |
| UniProt Protein Function: | CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integralCellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane; external side of plasma membraneMolecular Function: G-protein coupled receptor activity; signal transducer activity; protein binding; C-C chemokine receptor activity; cytokine binding; chemokine receptor activityBiological Process: positive regulation of T-helper 1 type immune response; sensory perception of pain; chemotaxis; signal transduction; regulation of cell migration; monocyte chemotaxis; hemopoiesis; angiogenesis; cellular homeostasis; inflammatory response; healing during inflammatory response; positive regulation of tumor necrosis factor biosynthetic process; cytokine and chemokine mediated signaling pathway; humoral immune response; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of interferon-gamma production; negative regulation of T-helper 2 type immune response; positive regulation of interleukin-2 production; cellular defense response; positive regulation of alpha-beta T cell proliferation; immune response; blood vessel remodeling; positive regulation of T cell activation; negative regulation of eosinophil degranulation; positive regulation of T-helper 1 cell differentiation; apoptotic cell clearance; positive regulation of inflammatory response |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P51683 |
| NCBI GenInfo Identifier: | 6753466 |
| NCBI Gene ID: | 12772 |
| NCBI Accession: | NP_034045.1 |
| UniProt Secondary Accession: | P51683,Q61172 |
| UniProt Related Accession: | P51683 |
| Molecular Weight: | 42,783 Da |
| NCBI Full Name: | C-C chemokine receptor type 2 |
| NCBI Synonym Full Names: | chemokine (C-C motif) receptor 2 |
| NCBI Official Symbol: | Ccr2 |
| NCBI Official Synonym Symbols: | Ckr2; Ccr2a; Ccr2b; Ckr2a; Ckr2b; mJe-r; Cmkbr2; Cc-ckr-2 |
| NCBI Protein Information: | C-C chemokine receptor type 2; CCR-2; C-C CKR-2; MIP-1 alphaR; MCP-1 receptor; JE/FIC receptor; chemokine (C-C) receptor 2; chemoattractant protein-1 receptor; C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR) |
| UniProt Protein Name: | C-C chemokine receptor type 2 |
| UniProt Synonym Protein Names: | JE/FIC receptor; MCP-1 receptor; CD_antigen: CD192 |
| Protein Family: | C-C chemokine receptor |
| UniProt Gene Name: | Ccr2 |
| UniProt Entry Name: | CCR2_MOUSE |
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