CASP10 Antibody (PACO00520)
- SKU:
- PACO00520
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | CASP10 Antibody |
| Antibody SKU: | PACO00520 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the C-terminal region of human Caspase-10 B/C. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | ALPS2; apoptotic protease Mch-4; CASP-10; CASPA; caspase-10; FADD-like ICE2; FAS-associated death domain protein interleukin-1B-convert |
| UniProt Protein Function: | CASP10: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit. Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10. Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon. Belongs to the peptidase C14A family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.22.63; ProteaseChromosomal Location of Human Ortholog: 2q33-q34Cellular Component: cytoplasm; plasma membrane; CD95 death-inducing signaling complex; cytosolMolecular Function: protein binding; cysteine-type endopeptidase activity; ubiquitin protein ligase bindingBiological Process: regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; innate immune response; proteolysisDisease: Lymphoma, Non-hodgkin, Familial; Gastric Cancer; Autoimmune Lymphoproliferative Syndrome, Type Iia |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] |
| UniProt Code: | Q92851-2 |
| NCBI GenInfo Identifier: | 12644463 |
| NCBI Gene ID: | 843 |
| NCBI Accession: | Q92851.3 |
| UniProt Secondary Accession: | Q92851-2,Q68HC0, Q6KF62, Q6KF63, Q8IUP5, Q8WYQ8, Q99845 Q9Y2U6, Q9Y2U7 |
| UniProt Related Accession: | Q92851-2,Q92851 |
| Molecular Weight: | 59kDa |
| NCBI Full Name: | Caspase-10 |
| NCBI Synonym Full Names: | caspase 10, apoptosis-related cysteine peptidase |
| NCBI Official Symbol: | CASP10 |
| NCBI Official Synonym Symbols: | MCH4; ALPS2; FLICE2 |
| NCBI Protein Information: | caspase-10; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine protease; FAS-associated death domain protein interleukin-1B-converting enzyme 2 |
| UniProt Protein Name: | Caspase-10 |
| UniProt Synonym Protein Names: | Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4Cleaved into the following 2 chains:Caspase-10 subunit p23/17; Caspase-10 subunit p12 |
| Protein Family: | Caspase |
| UniProt Gene Name: | CASP10 |
| UniProt Entry Name: | CASPA_HUMAN |
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