Description
system_update_alt Datasheet
Product Name: | CAPG Antibody |
Product Sku: | CPAB0654 |
Size: | 5μg |
Host Species: | Mouse |
Immunogen: | Anti-human CAPG mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CAPG amino acids 1-348 purified from Ecoli. |
Clone: | PAT1D10AT. |
Reactivity: | Other bodies |
Applications: | Western Blot, ELISA |
Purification Method: | CAPG antibody was purified from mouse ascitic fluids by protein-A affinity chromatography. |
Isotype: | IgG1 |
Background: | CAPG is part of the gelsolin/villin family of actin-regulatory proteins. CAPG reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated method, though it does not separate preformed actin filaments. By capping the barbed ends of actin filaments, CAPG contributes to the control of actin-based motility in non-muscle cells. CAPG is involved in macrophage function. CAPG is involved in regulating cytoplasmic and/or nuclear structures via possible interactions with actin. CAPG binds DNA. CAPG lacks a nuclear export sequence present in structurally related proteins. CAPG is a tumor suppressor protein that plays a role in the tumorigenic progression of certain cancers. Dysregulated expression of CAPG was found in premalignant and malignant oral carcinogenesis. |
Synonyms: | AFCP, CAPG, Macrophage-capping protein, Actin regulatory protein CAP-G, MCP. |
Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |