C3c Polyclonal Antibody
- SKU:
- CAB23938
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | C3c Polyclonal Antibody |
| Product Code: | CAB23938 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Positive Samples: | Hep G2 |
| Cellular Location: | Secreted |
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.
| Immunogen: | Recombinant protein of human C3c. |
| Sequence: | GRLKG PLLNK FLTTA KDKNR WEDPG KQLYN VEATS YALLA LLQLK DFDFV PPVVR WLNEQ RYYGG GYGST QATFM VFQAL AQYQK DAPDH QELNL DVSLQ L |
| Synonyms: | ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p |
| Calculated MW: | 187kDa |
| Observed MW: | 187kDa |
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