BTK Polyclonal Antibody
- SKU:
- CAB21618
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | BTK Polyclonal Antibody |
| Product Code: | CAB21618 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein |
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 173-272 of human BTK (NP_000052.1). |
| Sequence: | GSLKP GSSHR KTKKP LPPTP EEDQI LKKPL PPEPA AAPVS TSELK KVVAL YDYMP MNAND LQLRK GDEYF ILEES NLPWW RARDK NGQEG YIPSN YVTEA |
| Synonyms: | AT, ATK, BPK, XLA, IMD1, AGMX1, IGHD3, PSCTK1 |
| Calculated MW: | 76kDa |
| Observed MW: | Refer to figures |
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