Bak Polyclonal Antibody
- SKU:
- CAB21579
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Bak Polyclonal Antibody |
| Product Code: | CAB21579 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Mitochondrion membrane, Single-pass membrane protein |
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Bak (NP_001179.1). |
| Sequence: | MASGQ GPGPP RQECG EPALP SASEE QVAQD TEEVF RSYVF YRHQQ EQEAE GVAAP ADPEM VTLPL QPSST MGQVG RQLAI IGDDI NRRYD SEFQT MLQHL |
| Synonyms: | BAK, CDN1, BCL2L7, BAK-LIKE |
| Calculated MW: | 23kDa |
| Observed MW: | Refer to figures |
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