ATF2 Monoclonal Antibody
- SKU:
- CAB22718
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IP
Description
| Product Name: | ATF2 Monoclonal Antibody |
| Product Code: | CAB22718 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55522 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IP, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunoprecipitation |
| Recommended Dilution: | WB 1:10000-1:50000, IHC-P 1:500-1:1000, IP 1:10000-1:40000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | COLO 205(Negative control), HeLa, C2C12, Rat thymus |
| Cellular Location: | Cytoplasm, Mitochondrion outer membrane, Nucleus |
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-340 of human ATF2 (NP_001871.2). |
| Sequence: | MKFKL HVNSA RQYKD LWNMS DDKPF LCTAP GCGQR FTNED HLAVH KHKHE MTLKF GPARN DSVIV ADQTP TPTRF LKNCE EVGLF NELAS PFENE FKKAS EDDIK KMPLD LSPLA TPIIR SKIEE PSVVE TTHQD SPLPH PESTT SDEKE VPLAQ TAQPT SAIVR PASLQ VPNVL LTSSD SSVII QQAVP SPTSS TVITQ APSSN RPIVP VPGPF PLLLH LPNGQ TMPVA IPASI TSSNV HVPAA VPLVR PVTMV PSVPG IPGPS SPQPV QSEAK MRLKA ALTQQ HPPVT NGDTV KGHGS GLVRT QSEES RPQSL QQPAT STTET PASPA HTTPQ TQSTS |
| Synonyms: | HB16, CREB2, TREB7, CREB-2, CRE-BP1 |
| Calculated MW: | 55kDa |
| Observed MW: | 74kDa |
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