Developmental Biology

Anti-ZPR1 Antibody (CAB15746)

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SKU:
CAB15746
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-ZPR1 Antibody
Antibody SKU:CAB15746
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 110-459 of human ZPR1 (NP_003895.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-87MG
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 110-459 of human ZPR1 (NP_003895.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LEDM NREV VKTD SAAT RIPE LDFE IPAF SQKG ALTT VEGL ITRA ISGL EQDQ PARR ANKD ATAE RIDE FIVK LKEL KQVA SPFT LIID DPSG NSFV ENPH APQK DDAL VITH YNRT RQQE EMLG LQEE APAE KPEE EDLR NEVL QFST NCPE CNAP AQTN MKLV QIPH FKEV IIMA TNCE NCGH RTNE VKSG GAVE PLGT RITL HITD ASDM TRDL LKSE TCSV EIPE LEFE LGMA VLGG KFTT LEGL LKDI RELV TKNP FTLG DSSN PGQT ERLQ EFSQ KMDQ IIEG NMKA HFIM DDPA GNSY LQNV YAPE DDPE MKVE RYKR TFDQ NEEL GLND MKTE GYEA GLAP QR
Gene ID:8882
Uniprot:O75312
Cellular Location:Cajal body, Cell projection, Cytoplasm, Nucleus, axon, gem, growth cone, nucleolus, perinuclear region
Calculated MW:50kDa
Observed MW:55kDa
Synonyms:ZPR1, ZNF259
Background:The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:ZNF259: May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus. Binds to the EGF and PDGF receptors. Binds to the elongation factor 1-alpha EF1A. Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Belongs to the ZPR1 family.
UniProt Protein Details:

Protein type:Nucleolus; Cell cycle regulation

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: nucleoplasm; Cajal body; growth cone; cell soma; perinuclear region of cytoplasm; axon; cytoplasm; nucleolus; perikaryon; SMN complex; nucleus

Molecular Function:protein binding; zinc ion binding; translation initiation factor binding; receptor tyrosine kinase binding

Biological Process: cell proliferation; regulation of myelination; trophectodermal cell proliferation; positive regulation of protein import into nucleus; spinal cord development; RNA splicing; DNA endoreduplication; Cajal body organization and biogenesis; microtubule cytoskeleton organization and biogenesis; mRNA processing; signal transduction; positive regulation of RNA splicing; positive regulation of growth; inner cell mass cell proliferation

UniProt Code:O75312
NCBI GenInfo Identifier:6137318
NCBI Gene ID:8882
NCBI Accession:O75312.1
UniProt Secondary Accession:O75312,Q2TAA0,
UniProt Related Accession:O75312
Molecular Weight:459
NCBI Full Name:Zinc finger protein ZPR1
NCBI Synonym Full Names:ZPR1 zinc finger
NCBI Official Symbol:ZPR1  
NCBI Official Synonym Symbols:ZNF259  
NCBI Protein Information:zinc finger protein ZPR1; zinc finger protein 259
UniProt Protein Name:Zinc finger protein ZPR1
UniProt Synonym Protein Names:Zinc finger protein 259
Protein Family:Zinc finger protein
UniProt Gene Name:ZPR1  
UniProt Entry Name:ZPR1_HUMAN
Anti-ZPR1 Antibody (CAB15746)Western blot analysis of extracts of U-87MG cells, using ZPR1 antibody (CAB15746) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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