Developmental Biology

Anti-ZNF281 Antibody (CAB12650)

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SKU:
CAB12650
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-ZNF281 Antibody
Antibody SKU:CAB12650
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 676-895 of human ZNF281 (NP_036614.1).
Application:WB IHC
Recommended Dilution:WB 1:1000 - 1:3000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 676-895 of human ZNF281 (NP_036614.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:FEKS TNAS FTLG HGFQ FVSL SSPL HNHT LFPE KQIY TTSP LECG FGQS VTSV LPSS LPKP PFGM LFGS QPGL YLSA LDAT HQQL TPSQ ELDD LIDS QKNL ETSS AFQS SSQK LTSQ KEQK NLES STGF QIPS QELA SQID PQKD IEPR TTYQ IENF AQAF GSQF KSGS RVPM TFIT NSNG EVDH RVRT SVSD FSGY TNMM SDVS EPCS TRVK TPTS QSYR
Gene ID:23528
Uniprot:Q9Y2X9
Cellular Location:Nucleus
Calculated MW:93kDa/96kDa
Observed MW:110kDa
Synonyms:ZNF281, ZBP-99, ZNP-99
Background:
UniProt Protein Function:ZNF281: Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin and ornithine decarboxylase. Binds to the G-rich box in the enhancer region of these genes. Belongs to the krueppel C2H2-type zinc-finger protein family.
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: nucleoplasm; nucleus

Molecular Function:protein binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity

Biological Process: embryonic body morphogenesis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; stem cell differentiation

UniProt Code:Q9Y2X9
NCBI GenInfo Identifier:13124664
NCBI Gene ID:23528
NCBI Accession:Q9Y2X9.1
UniProt Secondary Accession:Q9Y2X9,Q5RKW5, Q9NY92, A6NF48, B3KMX2,
UniProt Related Accession:Q9Y2X9
Molecular Weight:93,232 Da
NCBI Full Name:Zinc finger protein 281
NCBI Synonym Full Names:zinc finger protein 281
NCBI Official Symbol:ZNF281  
NCBI Official Synonym Symbols:ZBP-99; ZNP-99  
NCBI Protein Information:zinc finger protein 281
UniProt Protein Name:Zinc finger protein 281
UniProt Synonym Protein Names:GC-box-binding zinc finger protein 1; Transcription factor ZBP-99; Zinc finger DNA-binding protein 99
Protein Family:Zinc finger protein
UniProt Gene Name:ZNF281  
UniProt Entry Name:ZN281_HUMAN
Anti-ZNF281 Antibody (CAB12650)Western blot analysis of extracts of mouse spleen, using ZNF281 antibody (CAB12650) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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