Developmental Biology

Anti-ZFPM2 Antibody (CAB9868)

(No reviews yet) Write a Review
SKU:
CAB9868
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Developmental Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-ZFPM2 Antibody
Antibody SKU:CAB9868
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 982-1151 of human ZFPM2 (NP_036214.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HT-1080, K-562, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 982-1151 of human ZFPM2 (NP_036214.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SPYY GIKP SDYI SGSL VIHN TDIE QSRN AENE SPKG QASS NGCA ALKK DSLP LLPK NRGM VIVN GGLK QDER PAAN PQQE NISQ NPQH EDDH KSPS WISE NPLA ANEN VSPG IPSA EEQL SSIA KGVN GSSQ APTS GKYC RLCD IQFN NLSN FITH KKFY CSSH AAEH VK
Gene ID:23414
Uniprot:Q8WW38
Cellular Location:Nucleus
Calculated MW:113kDa/128kDa
Observed MW:150kDa
Synonyms:ZFPM2, DIH3, FOG2, SRXY9, ZC2HC11B, ZNF89B, hFOG-2
Background:The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence.
UniProt Protein Function:FOG2: Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2. Defects in ZFPM2 may be a cause of tetralogy of Fallot (TOF). TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent. Defects in ZFPM2 are the cause of diaphragmatic hernia 3 (DIH3); a form of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension. Belongs to the FOG (Friend of GATA) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 8q23

Cellular Component: nucleoplasm; nucleus

Molecular Function:protein binding; transcription corepressor activity; transcription factor binding

Biological Process: blood coagulation; negative regulation of fat cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter

Disease: 46,xy Sex Reversal 9; Diaphragmatic Hernia 3; Tetralogy Of Fallot

NCBI Summary:The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]
UniProt Code:Q8WW38
NCBI GenInfo Identifier:126302543
NCBI Gene ID:23414
NCBI Accession:Q8WW38.3
UniProt Secondary Accession:Q8WW38,Q32MA6, Q9NPL7, Q9NPS4, Q9UNI5,
UniProt Related Accession:Q8WW38
Molecular Weight:113,229 Da
NCBI Full Name:Zinc finger protein ZFPM2
NCBI Synonym Full Names:zinc finger protein, FOG family member 2
NCBI Official Symbol:ZFPM2  
NCBI Official Synonym Symbols:DIH3; FOG2; SRXY9; ZNF89B; hFOG-2; ZC2HC11B  
NCBI Protein Information:zinc finger protein ZFPM2
UniProt Protein Name:Zinc finger protein ZFPM2
UniProt Synonym Protein Names:Friend of GATA protein 2; FOG-2; Friend of GATA 2; hFOG-2; Zinc finger protein 89B; Zinc finger protein multitype 2
Protein Family:Zinc finger protein
UniProt Gene Name:ZFPM2  
UniProt Entry Name:FOG2_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products