Cell Biology Antibodies 13
Anti-WWC1 Antibody (CAB17110)
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- SKU:
- CAB17110
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-WWC1 Antibody |
| Antibody SKU: | CAB17110 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 950-1050 of human WWC1 (NP_001155133.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Mouse lung, Mouse brain, Rat brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 950-1050 of human WWC1 (NP_001155133.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | STLS KKPP FVRN SLER RSVR MKRP SPPP QPSS VKSL RSER LIRT SLDL ELDL QATR TWHS QLTQ EISV LKEL KEQL EQAK SHGE KELP QWLR EDER FRLL L |
| Gene ID: | 23286 |
| Uniprot: | Q8IX03 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 125kDa |
 | Western blot - WWC1 Rabbit pAb (CAB17110) |
| Synonyms: | WWC1, HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168 |
| Background: | The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | KIBRA: a postsynaptic scaffolding protein associated with human memory performance. Interacts via its WW domains with the postsynaptic protein DDN, which plays a role in synaptic plasticity. Expressed in the hypothalamus and cerebellum, and in the hippocampus and cortex, both regions of the brain that are related to memory. Co-localizes with PKCZ in the mouse hippocampus. Binds to synaptopodin, modulating podocyte directional migration. Forms a complex with dynein light chain 1 that is recruited to ER-responsive promoters, and that is required for ER transactivation in breast cancer cells. Binds the minus end-directed microtubule motor dynein. Its amino terminus binds the eight PDZ domain of the polarity protein INADL. Two human isoforms have been described. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 5q34 Cellular Component: cytoplasm; cytosol; nucleus; perinuclear region of cytoplasm Molecular Function:kinase binding; protein binding; protein complex scaffold; transcription coactivator activity Biological Process: cell migration; establishment of cell polarity; negative regulation of organ growth; negative regulation of transcription from RNA polymerase II promoter; positive regulation of MAPKKK cascade; regulation of intracellular transport Disease: Memory Quantitative Trait Locus |
| NCBI Summary: | The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q8IX03 |
| NCBI GenInfo Identifier: | 74714457 |
| NCBI Gene ID: | 23286 |
| NCBI Accession: | Q8IX03.1 |
| UniProt Secondary Accession: | Q8IX03,O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29 B4DK05, |
| UniProt Related Accession: | Q8IX03 |
| Molecular Weight: | 125,905 Da |
| NCBI Full Name: | Protein KIBRA |
| NCBI Synonym Full Names: | WW and C2 domain containing 1 |
| NCBI Official Symbol: | WWC1 |
| NCBI Official Synonym Symbols: | KIBRA; HBEBP3; HBEBP36; MEMRYQTL; PPP1R168 |
| NCBI Protein Information: | protein KIBRA |
| UniProt Protein Name: | Protein KIBRA |
| UniProt Synonym Protein Names: | HBeAg-binding protein 3; Kidney and brain protein; KIBRA; WW domain-containing protein 1 |
| UniProt Gene Name: | WWC1 |
| UniProt Entry Name: | KIBRA_HUMAN |
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