Epigenetics & Nuclear Signaling Antibodies 5

Anti-WSTF Antibody (CAB9519)

(No reviews yet) Write a Review
SKU:
CAB9519
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-WSTF Antibody
Antibody SKU:CAB9519
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human WSTF
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, PC-12, SH-SY5Y, SKOV3, Mouse brain
Immunogen:A synthesized peptide derived from human WSTF
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9031
Uniprot:Q9UIG0
Cellular Location:
Calculated MW:185kDa
Observed MW:185KDa
Synonyms:WBSCR10, WBSCR9, WSTF
Background:This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008]
UniProt Protein Function:WSTF: plays a central role in chromatin remodeling and acts as a transcription regulator. Apparently possesses tyrosine-protein kinase activity, but bears no sequence resemblance classical tyrosine kinase proteins. Involved in DNA damage response by phosphorylating Y142 of histone H2AX. H2AXpY142 plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at Y142, and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. In the WINAC complex, plays an essential role by targeting the complex to acetylated histones, an essential step for VDR-promoter association. Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA. Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary. Two alternatively-spliced human isoforms have been reported.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Nuclear receptor co-regulator; Kinase, protein; EC 2.7.10.2; DNA replication; ATYPICAL group; BAZ family

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: nuclear replication fork; nucleoplasm

Molecular Function:chromatin binding; histone kinase activity; protein binding; protein-tyrosine kinase activity

Biological Process: chromatin-mediated maintenance of transcription; double-strand break repair; heart morphogenesis; histone phosphorylation; positive regulation of gene expression, epigenetic; regulation of transcription, DNA-dependent; response to DNA damage stimulus

NCBI Summary:This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UIG0
NCBI GenInfo Identifier:22653670
NCBI Gene ID:9031
NCBI Accession:Q9UIG0.2
UniProt Secondary Accession:Q9UIG0,O95039, O95247, O95277, Q6P1K4, Q86UJ6, B9EGK3 D3DXE9,
UniProt Related Accession:Q9UIG0
Molecular Weight:170,447 Da
NCBI Full Name:Tyrosine-protein kinase BAZ1B
NCBI Synonym Full Names:bromodomain adjacent to zinc finger domain 1B
NCBI Official Symbol:BAZ1B  
NCBI Official Synonym Symbols:WSTF; WBSCR9; WBSCR10  
NCBI Protein Information:tyrosine-protein kinase BAZ1B
UniProt Protein Name:Tyrosine-protein kinase BAZ1B
UniProt Synonym Protein Names:Bromodomain adjacent to zinc finger domain protein 1B; Williams syndrome transcription factor; Williams-Beuren syndrome chromosomal region 10 protein; Williams-Beuren syndrome chromosomal region 9 protein; hWALp2
Protein Family:Tyrosine-protein kinase
UniProt Gene Name:BAZ1B  
UniProt Entry Name:BAZ1B_HUMAN
Anti-WSTF Antibody (CAB9519)Western blot - WSTF Rabbit mAb (CAB9519)
View AllClose

0 Reviews

View AllClose

Related Products