Metabolism Antibodies 2
Anti-WNT7B Antibody (CAB17004)
- SKU:
- CAB17004
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-WNT7B Antibody |
| Antibody SKU: | CAB17004 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-349 of human WNT7B (NP_478679.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-549, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-349 of human WNT7B (NP_478679.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TAAC SQGN LSNC GCDR EKQG YYNQ AEGW KWGG CSAD VRYG IDFS RRFV DARE IKKN ARRL MNLH NNEA GRKV LEDR MQLE CKCH GVSG SCTT KTCW TTLP KFRE VGHL LKEK YNAA VQVE VVRA SRLR QPTF LRIK QLRS YQKP METD LVYI EKSP NYCE EDAA TGSV GTQG RLCN RTSP GADG CDTM CCGR GYNT HQYT KVWQ CNCK FHWC CFVK CNTC SERT EVFT CK |
| Gene ID: | 7477 |
| Uniprot: | P56706 |
| Cellular Location: | |
| Calculated MW: | 39kDa |
| Observed MW: | 39kDa |
| Synonyms: | WNT7B |
| Background: | This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. |
| UniProt Protein Function: | WNT7B: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Belongs to the Wnt family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 22q13 Cellular Component: proteinaceous extracellular matrix; extracellular space; endoplasmic reticulum lumen; Golgi lumen; plasma membrane; extracellular region Molecular Function:frizzled binding Biological Process: oxygen homeostasis; cell fate commitment; Wnt receptor signaling pathway; in utero embryonic development; response to glucocorticoid stimulus; positive regulation of JNK cascade; Wnt receptor signaling pathway through beta-catenin; forebrain regionalization; anatomical structure regression; activation of JNK activity; odontogenesis of dentine-containing teeth; neuron differentiation; positive regulation of osteoblast differentiation; cellular metabolic process; central nervous system vasculogenesis; fibroblast proliferation; homeostatic process; negative regulation of smoothened signaling pathway; positive regulation of cell proliferation; regulation of cell projection size; synapse organization and biogenesis; embryonic organ development; smooth muscle cell differentiation; establishment and/or maintenance of polarity of embryonic epithelium; neurite morphogenesis; lung development |
| NCBI Summary: | This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P56706 |
| NCBI GenInfo Identifier: | 119593800 |
| NCBI Gene ID: | 7477 |
| NCBI Accession: | EAW73394.1 |
| UniProt Secondary Accession: | P56706,Q96Q12, B8A596, |
| UniProt Related Accession: | P56706 |
| Molecular Weight: | 39,327 Da |
| NCBI Full Name: | wingless-type MMTV integration site family, member 7B |
| NCBI Synonym Full Names: | wingless-type MMTV integration site family, member 7B |
| NCBI Official Symbol: | WNT7B |
| NCBI Protein Information: | protein Wnt-7b |
| UniProt Protein Name: | Protein Wnt-7b |
| Protein Family: | Protein |
| UniProt Gene Name: | WNT7B |
| UniProt Entry Name: | WNT7B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using WNT7B antibody (CAB17004) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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