Cell Biology Antibodies 14
Anti-WIPF1 Antibody (CAB17003)
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- SKU:
- CAB17003
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-WIPF1 Antibody |
| Antibody SKU: | CAB17003 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human WIPF1 (NP_001070737.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | RAW264.7, Mouse spleen |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human WIPF1 (NP_001070737.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QLPS RSGV DSPR SGPR PPLP PDRP SAGA PPPP PPST SIRN GFQD SPCE DEWE SRFY FHPI SDLP PPEP YVQT TKSY PSKL ARNE SRSG SNRR ERGA PPLP P |
| Gene ID: | 7456 |
| Uniprot: | O43516 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 51kDa |
 | Western blot - WIPF1 Rabbit pAb (CAB17003) |
| Synonyms: | WIPF1, PRPL-2, WAS2, WASPIP, WIP |
| Background: | This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. |
| UniProt Protein Function: | WIPF1: a cytoskeleton-associated protein that interacts with the Wiskott-Aldrich syndrome protein (WASP) in resting cells. Plays an important role in the organization of the actin cytoskeleton. Phosphorylation by PKC-theta following T cell receptor signaling disengages it from WASP, releasing WASP from WIP inhibition. Binds to a region of WASP that is frequently mutated in Wiskott-Aldrich syndrome. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: actin cytoskeleton; actin filament; cytoplasmic membrane-bound vesicle; cytosol; ruffle Molecular Function:actin binding; actin filament binding; profilin binding; protein binding Biological Process: actin cortical patch assembly; actin cortical patch localization; actin filament-based movement; actin polymerization and/or depolymerization; endocytosis; innate immune response; positive regulation of actin nucleation; protein complex assembly; regulation of cell shape; response to other organism; small GTPase mediated signal transduction Disease: Wiskott-aldrich Syndrome 2 |
| NCBI Summary: | This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43516 |
| NCBI GenInfo Identifier: | 313104260 |
| NCBI Gene ID: | 7456 |
| NCBI Accession: | O43516.3 |
| UniProt Secondary Accession: | O43516,Q15220, Q53TA9, Q6MZU9, Q9BU37, Q9UNP1, B8ZZM1 D3DPE4, |
| UniProt Related Accession: | O43516 |
| Molecular Weight: | 36,426 Da |
| NCBI Full Name: | WAS/WASL-interacting protein family member 1 |
| NCBI Synonym Full Names: | WAS/WASL interacting protein family member 1 |
| NCBI Official Symbol: | WIPF1 |
| NCBI Official Synonym Symbols: | WIP; WAS2; PRPL-2; WASPIP |
| NCBI Protein Information: | WAS/WASL-interacting protein family member 1 |
| UniProt Protein Name: | WAS/WASL-interacting protein family member 1 |
| UniProt Synonym Protein Names: | Protein PRPL-2; Wiskott-Aldrich syndrome protein-interacting protein; WASP-interacting protein |
| Protein Family: | WAS/WASL-interacting protein family |
| UniProt Gene Name: | WIPF1 |
| UniProt Entry Name: | WIPF1_HUMAN |
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