Antibody Name:	Anti-WDR5 Antibody
Antibody SKU:	CAB2023
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human WDR5 (NP_438172.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse
Positive Samples:	293T, 22Rv1, BT-474, HeLa

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human WDR5 (NP_438172.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MATE EKKP ETEA ARAQ PTPS SSAT QSKP TPVK PNYA LKFT LAGH TKAV SSVK FSPN GEWL ASSS ADKL IKIW GAYD GKFE KTIS GHKL GISD VAWS SDSN LLVS ASDD KTLK IWDV SSGK CLKT LKGH SNYV FCCN FNPQ SNLI VSGS FDES VRIW DVKT GKCL KTLP AHSD PVSA VHFN RDGS LIVS SSYD GLCR IWDT ASGQ CLKT LIDD DNPP VSFV KFSP NGKY ILAA TLDN TLKL WDYS KGKC LKTY TGHK NEKY CIFA NFSV TGGK WIVS GSED NLVY IWNL QTKE IVQK LQGH TDVV ISTA CHPT ENII ASAA LEND KTIK LWKS DC
Gene ID:	11091
Uniprot:	P61964
Cellular Location:	Nucleus
Calculated MW:	36kDa
Observed MW:	37kDa

Synonyms:

WDR5, BIG-3, CFAP89, SWD3

Background:

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.

UniProt Protein Function:	WDR5: a WD40 repeat protein. May accelerate osteoblast differentiation. Interacts with HCFC1. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.
UniProt Protein Details:	Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 9q34 Cellular Component: histone acetyltransferase complex; histone methyltransferase complex; nucleoplasm; nucleus Molecular Function:histone acetyltransferase activity (H4-K16 specific); histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; methylated histone residue binding; protein binding Biological Process: histone H3-K4 methylation
NCBI Summary:	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:	P61964
NCBI GenInfo Identifier:	48429182
NCBI Gene ID:	11091
NCBI Accession:	P61964.1
UniProt Secondary Accession:	P61964,Q91VA5, Q9NWX7, Q9UGP9,
UniProt Related Accession:	P61964
Molecular Weight:	36,588 Da
NCBI Full Name:	WD repeat-containing protein 5
NCBI Synonym Full Names:	WD repeat domain 5
NCBI Official Symbol:	WDR5
NCBI Official Synonym Symbols:	SWD3; BIG-3; CFAP89
NCBI Protein Information:	WD repeat-containing protein 5
UniProt Protein Name:	WD repeat-containing protein 5
UniProt Synonym Protein Names:	BMP2-induced 3-kb gene protein
Protein Family:	WD repeat-containing protein
UniProt Gene Name:	WDR5
UniProt Entry Name:	WDR5_HUMAN

	Western blot analysis of extracts of various cell lines, using WDR5 antibody (CAB2023) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
	Immunohistochemistry of paraffin-embedded human kidney cancer using WDR5 antibody (CAB2023) at dilution of 1:200 (40x lens).