Description
| Antibody Name: | Anti-VTN Antibody |
| Antibody SKU: | CAB1667 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 364-478 of human VTN (NP_000629.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Human serum, Rat serum |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 364-478 of human VTN (NP_000629.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SLAK KQRF RHRN RKGY RSQR GHSR GRNQ NSRR PSRA TWLS LFSS EESN LGAN NYDD YRMD WLVP ATCE PIQS VFFF SGDK YYRV NLRT RRVD TVDP PYPR SIAQ YWLG CPAP GHL |
| Gene ID: | 7448 |
| Uniprot: | P04004 |
| Cellular Location: | Secreted, extracellular space |
| Calculated MW: | 54kDa |
| Observed MW: | 65kDa, 75kDa |
| Synonyms: | VTN, V75, VN, VNT |
| Background: | The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. |
| UniProt Protein Function: | VTN: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 17q11 Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region Molecular Function:heparin binding; integrin binding; protein binding; extracellular matrix binding; scavenger receptor activity; polysaccharide binding Biological Process: receptor-mediated endocytosis; extracellular matrix organization and biogenesis; positive regulation of protein binding; cell-matrix adhesion; negative regulation of blood coagulation; positive regulation of smooth muscle cell migration; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of receptor-mediated endocytosis; positive regulation of peptidyl-tyrosine phosphorylation; regulation of complement activation; cell adhesion mediated by integrin; innate immune response; immune response; cell adhesion |
| NCBI Summary: | The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P04004 |
| NCBI GenInfo Identifier: | 139653 |
| NCBI Gene ID: | 7448 |
| NCBI Accession: | P04004.1 |
| UniProt Related Accession: | P04004 |
| Molecular Weight: | |
| NCBI Full Name: | Vitronectin |
| NCBI Synonym Full Names: | vitronectin |
| NCBI Official Symbol: | VTN |
| NCBI Official Synonym Symbols: | VN; V75; VNT |
| NCBI Protein Information: | vitronectin |
| UniProt Protein Name: | Vitronectin |
| UniProt Synonym Protein Names: | S-protein; Serum-spreading factor; V75Cleaved into the following 3 chains:Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B |
| Protein Family: | Vitronectin |
| UniProt Gene Name: | VTN |
| UniProt Entry Name: | VTNC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using VTN antibody (CAB1667) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
 | Immunohistochemistry of paraffin-embedded mouse lung using VTN antibody (CAB1667) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse leydig cells using VTN antibody (CAB1667) at dilution of 1:100 (40x lens). |
Additional Information
Product Type: |
Antibody |
Reactivity: |
Human |
Reactivity: |
Mouse |
Reactivity: |
Rat |
Host Species: |
Rabbit |
Isotype: |
IgG |
Antibody Type: |
Polyclonal Antibody |
Research Area: |
Cell Biology |
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