Anti-VDR Antibody (CAB20840)
- SKU:
- CAB20840
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
| Antibody Name: | Anti-VDR Antibody (CAB20840) |
| Antibody SKU: | CAB20840 |
| Antibody Size: | 50µL, 100µL |
| Application: | Western blotting |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human VDR (NP_000367.1). |
| Application: | Western blotting |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human VDR (NP_000367.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEAM AAST SLPD PGDF DRNV PRIC GVCG DRAT GFHF NAMT CEGC KGFF RRSM KRKA LFTC PFNG DCRI TKDN RRHC QACR LKRC VDIG MMKE FILT DEEV QRKR EMIL KRKE EEAL KDSL RPKL SEEQ QRII AILL DAHH KTYD PTYS DFCQ FRPP VRVN DGGG SHPS RPNS RHTP SFSG DSSS SCSD HCIT SSDM MDSS SFSN LDLS EEDS DDPS VTLE LSQL SMLP HLAD LVSY SIQK VIGF AKMI PGFR DLTS EDQI VLLK SSAI EVIM LRSN ESFT MDDM SWTC GNQD YKYR VSDV |
| Cellular Location: | Nucleus |
| Calculated MW: | 48kDa/53kDa |
| Observed MW: | 48KDa |
| Synonyms: | VDR, NR1I1, PPP1R163 |
| Background: | This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. |
 | Western blot analysis of extracts of various cell lines, using VDR antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s. |
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