Cell Biology Antibodies 17
Anti-VCAM1 Antibody (CAB19131)
- SKU:
- CAB19131
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-VCAM1 Antibody |
Antibody SKU: | CAB19131 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB IF |
Reactivity: | Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthesized peptide derived from human VCAM1 |
Application: | WB IF |
Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
Reactivity: | Mouse, Rat |
Positive Samples: | Rat lung |
Immunogen: | A synthesized peptide derived from human VCAM1 |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 7412 |
Uniprot: | P19320 |
Cellular Location: | |
Calculated MW: | 100kDa |
Observed MW: | 110KDa |
Synonyms: | CD106, INCAM-100, VCAM1 |
Background: | This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010] |
UniProt Protein Function: | VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 1p32-p31 Cellular Component: Golgi apparatus; extracellular space; cell surface; microvillus; endoplasmic reticulum; early endosome; integral to membrane; apical part of cell; plasma membrane; podosome; sarcolemma; filopodium; external side of plasma membrane Molecular Function:amine oxidase activity; integrin binding; cell adhesion molecule binding Biological Process: response to nicotine; regulation of immune response; chronic inflammatory response; extracellular matrix organization and biogenesis; viral reproduction; heart development; cytokine and chemokine mediated signaling pathway; cell-matrix adhesion; response to lipopolysaccharide; heterophilic cell adhesion; leukocyte adhesion; response to ethanol; response to zinc ion; B cell differentiation; membrane to membrane docking; response to hypoxia; positive regulation of T cell proliferation; amine metabolic process; response to ionizing radiation; cell adhesion; leukocyte tethering or rolling; acute inflammatory response; response to nutrient; aging |
NCBI Summary: | This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | P19320 |
NCBI GenInfo Identifier: | 137560 |
NCBI Gene ID: | 7412 |
NCBI Accession: | P19320.1 |
UniProt Secondary Accession: | P19320,Q6NUP8, A8K6R7, B4DKS4, E9PDD1, |
UniProt Related Accession: | P19320 |
Molecular Weight: | 74,346 Da |
NCBI Full Name: | Vascular cell adhesion protein 1 |
NCBI Synonym Full Names: | vascular cell adhesion molecule 1 |
NCBI Official Symbol: | VCAM1 |
NCBI Official Synonym Symbols: | CD106; INCAM-100 |
NCBI Protein Information: | vascular cell adhesion protein 1; CD106 antigen |
UniProt Protein Name: | Vascular cell adhesion protein 1 |
UniProt Synonym Protein Names: | INCAM-100; CD_antigen: CD106 |
Protein Family: | Vascular cell adhesion protein |
UniProt Gene Name: | VCAM1 |
UniProt Entry Name: | VCAM1_HUMAN |