Cardiovascular Antibodies

Anti-VAV2 Antibody (CAB9483)

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SKU:
CAB9483
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cardiovascular

Description

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Antibody Name:Anti-VAV2 Antibody
Antibody SKU:CAB9483
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 570-700 of human VAV2 (NP_001127870.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, 293T, HeLa, HepG2, Mouse liver, Mouse lung, Mouse spleen, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 570-700 of human VAV2 (NP_001127870.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PPCK FTSP ADLD ASGA GPGP KMVA MQNY HGNP APPG KPVL TFQT GDVL ELLR GDPE SPWW EGRL VQTR KSGY FPSS SVKP CPVD GRPP ISRP PSRE IDYT AYPW FAGN MERQ QTDN LLKS HASG TYLI RER
Gene ID:7410
Uniprot:P52735
Cellular Location:
Calculated MW:97kDa/100kDa/101kDa
Observed MW:101kDa
Synonyms:VAV2, VAV-2
Background:VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:VAV2: a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed in most tissues.
UniProt Protein Details:

Protein type:GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q34.2

Cellular Component: cytosol

Molecular Function:guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: ephrin receptor signaling pathway; platelet activation; positive regulation of apoptosis; regulation of blood coagulation; regulation of cell size; regulation of gene expression; regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction; vascular endothelial growth factor receptor signaling pathway

NCBI Summary:VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
UniProt Code:P52735
NCBI GenInfo Identifier:212287930
NCBI Gene ID:7410
NCBI Accession:P52735.2
UniProt Secondary Accession:P52735,Q5SYV3, Q5SYV4, Q5SYV5, Q6N012, Q6PIJ9, Q6Q317 A2RUM4, A8MQ12, B6ZDF5,
UniProt Related Accession:P52735
Molecular Weight:97,032 Da
NCBI Full Name:Guanine nucleotide exchange factor VAV2
NCBI Synonym Full Names:vav guanine nucleotide exchange factor 2
NCBI Official Symbol:VAV2  
NCBI Official Synonym Symbols:VAV-2  
NCBI Protein Information:guanine nucleotide exchange factor VAV2
UniProt Protein Name:Guanine nucleotide exchange factor VAV2
Protein Family:Guanine nucleotide exchange factor
UniProt Gene Name:VAV2  
Anti-VAV2 Polyclonal Antibody (CAB9483)Western blot analysis of extracts of various cell lines, using VAV2 antibody (CAB9483) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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