Anti-VAV2 Antibody (CAB3548)

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SKU:
CAB3548
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
VAV-2
Research Area:
Cardiovascular

Description

Product Name:VAV2 Rabbit mAb
Product Code:CAB3548
Size:20uL, 50uL, 100uL
Synonyms:VAV-2
Applications:WB, IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human VAV2
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa, MCF7, SH-SY5Y, Mouse lung, Mouse liver, Mouse spleen
Immunogen:A synthesized peptide derived from human VAV2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7410
Uniprot:P52735
Calculated MW:100kDa
Observed MW:100kDa
UniProt Protein Function:VAV2: a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed in most tissues.
UniProt Protein Details:

Protein type:GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q34.2

Cellular Component: cytosol

Molecular Function:guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: ephrin receptor signaling pathway; platelet activation; positive regulation of apoptosis; regulation of blood coagulation; regulation of cell size; regulation of gene expression; regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction; vascular endothelial growth factor receptor signaling pathway

NCBI Summary:VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
UniProt Code:P52735
NCBI GenInfo Identifier:212287930
NCBI Gene ID:7410
NCBI Accession:P52735.2
UniProt Secondary Accession:P52735,Q5SYV3, Q5SYV4, Q5SYV5, Q6N012, Q6PIJ9, Q6Q317 A2RUM4, A8MQ12, B6ZDF5,
UniProt Related Accession:P52735
Molecular Weight:97,032 Da
NCBI Full Name:Guanine nucleotide exchange factor VAV2
NCBI Synonym Full Names:vav guanine nucleotide exchange factor 2
NCBI Official Symbol:VAV2  
NCBI Official Synonym Symbols:VAV-2  
NCBI Protein Information:guanine nucleotide exchange factor VAV2
UniProt Protein Name:Guanine nucleotide exchange factor VAV2
Protein Family:Guanine nucleotide exchange factor
UniProt Gene Name:VAV2  
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