Cell Death Antibodies 2
Anti-UXT Antibody (CAB4217)
- SKU:
- CAB4217
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-UXT Antibody |
| Antibody SKU: | CAB4217 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 13-169 of human UXT (NP_705582.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T, HL-60 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 13-169 of human UXT (NP_705582.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MATP PKRR AVEA TGEK VLRY ETFI SDVL QRDL RKVL DHRD KVYE QLAK YLQL RNVI ERLQ EAKH SELY MQVD LGCN FFVD TVVP DTSR IYVA LGYG FFLE LTLA EALK FIDR KSSL LTEL SNSL TKDS MNIK AHIH MLLE GLRE LQGL QNFP EKPH H |
| Gene ID: | 8409 |
| Uniprot: | Q9UBK9 |
| Cellular Location: | Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center |
| Calculated MW: | 18kDa |
| Observed MW: | 17kDa |
| Synonyms: | UXT, ART-27, STAP1 |
| Background: | The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | UXT: Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region. Belongs to the UXT family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: Xp11.23-p11.22 Cellular Component: centrosome; cytoskeleton; cytoplasm; nucleus; gamma-tubulin complex Molecular Function:actin filament binding; protein binding; microtubule binding; beta-tubulin binding; chromatin binding Biological Process: transcription, DNA-dependent; centrosome organization and biogenesis; negative regulation of transcription from RNA polymerase II promoter; microtubule cytoskeleton organization and biogenesis; mitochondrion transport along microtubule |
| NCBI Summary: | The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9UBK9 |
| NCBI GenInfo Identifier: | 8928445 |
| NCBI Gene ID: | 8409 |
| NCBI Accession: | Q9UBK9.1 |
| UniProt Secondary Accession: | Q9UBK9,Q5JZG3, Q9Y6E5, B2R561, |
| UniProt Related Accession: | Q9UBK9 |
| Molecular Weight: | 157 |
| NCBI Full Name: | Protein UXT |
| NCBI Synonym Full Names: | ubiquitously-expressed, prefoldin-like chaperone |
| NCBI Official Symbol: | UXT |
| NCBI Official Synonym Symbols: | STAP1; ART-27 |
| NCBI Protein Information: | protein UXT; SKP2-associated alpha PFD 1; ubiquitously expressed transcript protein; androgen receptor trapped clone 27 protein |
| UniProt Protein Name: | Protein UXT |
| UniProt Synonym Protein Names: | Androgen receptor trapped clone 27 protein; ART-27; Ubiquitously expressed transcript protein |
| Protein Family: | Protein |
| UniProt Gene Name: | UXT |
| UniProt Entry Name: | UXT_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UXT antibody (CAB4217) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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