Epigenetics & Nuclear Signaling Antibodies 4
Anti-UVRAG Antibody (CAB8462)
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- SKU:
- CAB8462
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-UVRAG Antibody |
| Antibody SKU: | CAB8462 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 501-699 of human UVRAG (NP_003360.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | LO2, HeLa, Mouse liver, Rat liver, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 501-699 of human UVRAG (NP_003360.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KGHR KRAS SENE RLQY KTPP PSYN SALA QPVT TVPS MGET ERKI TSLS SSLD TSLD FSKE NKKK GEDL VGSL NGGH ANVH PSQE QGEA LSGH RATV NGTL LPSE QAGS ASVQ LPGE FHPV SEAE LCCT VEQA EEII GLEA TGFA SGDQ LEAF NCIP VDSA VAVE CDEQ VLGE FEEF SRRI YALN ENVS SFRR PRRS SDK |
| Gene ID: | 7405 |
| Uniprot: | Q9P2Y5 |
| Cellular Location: | Chromosome, Early endosome, Endoplasmic reticulum, Late endosome, Lysosome, Midbody, centromere |
| Calculated MW: | 35kDa/78kDa |
| Observed MW: | 100kDa |
| Synonyms: | UVRAG, DHTX, VPS38, p63 |
| Background: | This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. |
| UniProt Protein Function: | UVRAG: Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition. Highly expressed in brain, lung, kidney and liver. |
| UniProt Protein Details: | Protein type:Autophagy Chromosomal Location of Human Ortholog: 11q13.5 Cellular Component: centrosome; cytoplasm; early endosome; endoplasmic reticulum; late endosome; lysosome; midbody Molecular Function:protein binding; SNARE binding Biological Process: autophagy; centrosome organization and biogenesis; DNA repair; maintenance of Golgi localization; receptor catabolic process; regulation of cytokinesis; retrograde vesicle-mediated transport, Golgi to ER |
| NCBI Summary: | This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9P2Y5 |
| NCBI GenInfo Identifier: | 20140879 |
| NCBI Gene ID: | 7405 |
| NCBI Accession: | Q9P2Y5.1 |
| UniProt Secondary Accession: | Q9P2Y5,O00392, B3KTC1, |
| UniProt Related Accession: | Q9P2Y5 |
| Molecular Weight: | 35,988 Da |
| NCBI Full Name: | UV radiation resistance-associated gene protein |
| NCBI Synonym Full Names: | UV radiation resistance associated |
| NCBI Official Symbol: | UVRAG |
| NCBI Official Synonym Symbols: | p63; DHTX; VPS38 |
| NCBI Protein Information: | UV radiation resistance-associated gene protein |
| UniProt Protein Name: | UV radiation resistance-associated gene protein |
| UniProt Synonym Protein Names: | p63 |
| Protein Family: | UV radiation resistance associated protein |
| UniProt Gene Name: | UVRAG |
| UniProt Entry Name: | UVRAG_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UVRAG antibody (CAB8462) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded human liver damage using UVRAG antibody (CAB8462) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat lung using UVRAG antibody (CAB8462) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using UVRAG antibody (CAB8462) at dilution of 1:100 (40x lens). |
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