Signal Transduction Antibodies 2

Anti-USP6NL Antibody (CAB15763)

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SKU:
CAB15763
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-USP6NL Antibody
Antibody SKU:CAB15763
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human USP6NL (NP_055503.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, LO2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human USP6NL (NP_055503.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SYTI LKLH KKHL MKLS MEEL VEFF QETL AKDF FFED DFVI EQLQ ISMT ELKR AKLD LPEP GKED EYPK KPLG QLPP ELQS WGVH HLSN GQRS VGRP SPLA SGRR ESGA PHRR HEHS PHPQ SRTG TPER AQPP RRKS VEEE SKKL KDEA DFQR KLPS GPQD SSRQ YNHA AANQ NSNA TSNI RKEF VPKW NKPS DVSA TERT AKYT MEGK GRAA HPAL AVTV PGPA EVRV SNVR PKMK ALDA EDGK RGST ASQY DNVP GPEL DSGA SVEE ALER AYSQ SPRH ALYP PSPR KHAE PSSS PSKV S
Gene ID:9712
Uniprot:Q92738
Cellular Location:Cytoplasmic vesicle, Golgi apparatus
Calculated MW:94kDa/95kDa
Observed MW:115kDa
Synonyms:USP6NL, RNTRE, TRE2NL, USP6NL-IT1
Background:
UniProt Protein Function:USP6NL: a widely-expressed GTPase activating protein (GAP) for RAB5A. Involved in endosomal trafficking, and localizes to the centrosome. In complex with Eps8 inhibits internalization of EGFR.
UniProt Protein Details:

Protein type:GAPs, Rab; Ubiquitin-specific protease; GAPs

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: cytoplasmic vesicle; cytosol; endomembrane system; plasma membrane; trans-Golgi network membrane

Molecular Function:GTPase activator activity; Rab GTPase binding

Biological Process: Golgi organization and biogenesis; intracellular protein transport; plasma membrane to endosome transport; regulation of vesicle fusion; virus assembly

UniProt Code:Q92738
NCBI GenInfo Identifier:34193210
NCBI Gene ID:9712
NCBI Accession:BC042943
UniProt Secondary Accession:Q92738,Q15400, Q5VV10, Q7L0K9, A8KA79,
UniProt Related Accession:Q92738
Molecular Weight:95,997 Da
NCBI Full Name:Homo sapiens USP6 N-terminal like, mRNA
NCBI Synonym Full Names:USP6 N-terminal like
NCBI Official Symbol:USP6NL  
NCBI Official Synonym Symbols:RNTRE; TRE2NL; USP6NL-IT1  
NCBI Protein Information:USP6 N-terminal-like protein
UniProt Protein Name:USP6 N-terminal-like protein
UniProt Synonym Protein Names:Related to the N-terminus of tre; RN-tre
Protein Family:USP6 N-terminal-like protein
UniProt Gene Name:USP6NL  
UniProt Entry Name:US6NL_HUMAN
Anti-USP6NL Antibody (CAB15763)Western blot analysis of extracts of various cell lines, using USP6NL antibody (CAB15763) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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