Cell Biology Antibodies 9
Anti-UQCRC2 Antibody (CAB4181)
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- SKU:
- CAB4181
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-UQCRC2 Antibody |
| Antibody SKU: | CAB4181 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 224-453 of human UQCRC2 (NP_003357.2). |
| Application: | WB IHC IP |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-251MG, MCF7, HepG2, H460, Mouse kidney, Mouse brain, Mouse liver, Rat spinal cord, Rat testis, NCI-H460 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 224-453 of human UQCRC2 (NP_003357.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GVSH PVLK QVAE QFLN MRGG LGLS GAKA NYRG GEIR EQNG DSLV HAAF VAES AVAG SAEA NAFS VLQH VLGA GPHV KRGS NTTS HLHQ AVAK ATQQ PFDV SAFN ASYS DSGL FGIY TISQ ATAA GDVI KAAY NQVK TIAQ GNLS NTDV QAAK NKLK AGYL MSVE SSEC FLEE VGSQ ALVA GSYM PPST VLQQ IDSV ANAD IINA AKKF VSGQ KSMA ASGN LGHT PFVD EL |
| Gene ID: | 7385 |
| Uniprot: | P22695 |
| Cellular Location: | Matrix side, Mitochondrion inner membrane, Peripheral membrane protein |
| Calculated MW: | 48kDa |
| Observed MW: | 48kDa |
| Synonyms: | UQCRC2, MC3DN5, QCR2, UQCR2 |
| Background: | The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. |
| UniProt Protein Function: | UQCRC2: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex. Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily. |
| UniProt Protein Details: | Protein type:EC 1.10.2.2; Mitochondrial; Oxidoreductase; Energy Metabolism - oxidative phosphorylation Chromosomal Location of Human Ortholog: 16p12 Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial respiratory chain complex III Molecular Function:protein binding; metal ion binding; metalloendopeptidase activity; protein complex binding Biological Process: cellular metabolic process; aerobic respiration; proteolysis; oxidative phosphorylation Disease: Mitochondrial Complex Iii Deficiency, Nuclear Type 5 |
| NCBI Summary: | The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P22695 |
| NCBI GenInfo Identifier: | 21903482 |
| NCBI Gene ID: | 7385 |
| NCBI Accession: | P22695.3 |
| UniProt Secondary Accession: | P22695,Q9DB77, P32551, |
| UniProt Related Accession: | P22695 |
| Molecular Weight: | 48kDa |
| NCBI Full Name: | Cytochrome b-c1 complex subunit 2, mitochondrial |
| NCBI Synonym Full Names: | ubiquinol-cytochrome c reductase core protein 2 |
| NCBI Official Symbol: | UQCRC2 |
| NCBI Official Synonym Symbols: | QCR2; UQCR2; MC3DN5 |
| NCBI Protein Information: | cytochrome b-c1 complex subunit 2, mitochondrial |
| UniProt Protein Name: | Cytochrome b-c1 complex subunit 2, mitochondrial |
| UniProt Synonym Protein Names: | Complex III subunit 2; Core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2 |
| UniProt Gene Name: | UQCRC2 |
| UniProt Entry Name: | QCR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UQCRC2 antibody (CAB4181) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded human colon using UQCRC2 Rabbit pAb (CAB4181) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat kidney using UQCRC2 Rabbit pAb (CAB4181) at dilution of 1:100 (40x lens). |
 | Immunoprecipitation analysis of 200ug extracts of HepG2 cells using 1ug UQCRC2 antibody (CAB4181). Western blot was performed from the immunoprecipitate using UQCRC2 antibody (CAB4181) at a dilition of 1:1000. |
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