Cell Biology Antibodies 13

Anti-UGT1A6 Antibody (CAB17166)

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SKU:
CAB17166
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-UGT1A6 Antibody
Antibody SKU:CAB17166
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 65-270 of human UGT1A6 (NP_001063.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:A-431, HT-29, Mouse liver, Mouse kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 65-270 of human UGT1A6 (NP_001063.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLLK ESKY YTRK IYPV PYDQ EELK NRYQ SFGN NHFA ERSF LTAP QTEY RNNM IVIG LYFI NCQS LLQD RDTL NFFK ESKF DALF TDPA LPCG VILA EYLG LPSV YLFR GFPC SLEH TFSR SPDP VSYI PRCY TKFS DHMT FSQR VANF LVNL LEPY LFYC LFSK YEEL ASAV LKRD VDII TLYQ KVSV WLLR YDFV LEYP RPVM PN
Gene ID:54578
Uniprot:P19224
Cellular Location:Endoplasmic reticulum membrane, Microsome, Single-pass membrane protein
Calculated MW:29kDa/50kDa/60kDa
Observed MW:70kDa
Anti-UGT1A6 Antibody (CAB17166)Western blot - UGT1A6 Rabbit pAb (CAB17166)
Synonyms:UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT 1-6, UGT1, UGT1A6S, UGT1F, UDPGT1-6
Background:This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.
UniProt Protein Function:Ugt1a6a: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - starch and sucrose; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.4.1.17; Carbohydrate Metabolism - pentose and glucuronate interconversions; Lipid Metabolism - androgen and estrogen; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Carbohydrate Metabolism - ascorbate and aldarate; Mitochondrial; Cofactor and Vitamin Metabolism - retinol

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function:protein homodimerization activity; enzyme binding; retinoic acid binding; protein heterodimerization activity; glucuronosyltransferase activity

Biological Process: negative regulation of transferase activity; flavonoid biosynthetic process; xenobiotic metabolic process; negative regulation of fatty acid metabolic process; drug metabolic process; cellular response to hormone stimulus

NCBI Summary:This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008]
UniProt Code:P19224
NCBI GenInfo Identifier:340141
NCBI Gene ID:54578
NCBI Accession:AAC41717.1
UniProt Secondary Accession:P19224,Q96TE7, A6NKK6, B8K289,
UniProt Related Accession:P19224
Molecular Weight:50,528 Da
NCBI Full Name:UDP-glucuronosyltransferase, partial
NCBI Synonym Full Names:UDP glucuronosyltransferase 1 family, polypeptide A6
NCBI Official Symbol:UGT1A6  
NCBI Official Synonym Symbols:GNT1; UGT1; HLUGP; UDPGT; UGT1F; HLUGP1; UGT1A6S; UDPGT 1-6  
NCBI Protein Information:UDP-glucuronosyltransferase 1-6; UGT-1F; UGT1*6; UGT1-06; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; phenol-metabolizing UDP-glucuronosyltransferase; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1 family polypeptide A6s
UniProt Protein Name:UDP-glucuronosyltransferase 1-6
UniProt Synonym Protein Names:Phenol-metabolizing UDP-glucuronosyltransferase; UDP-glucuronosyltransferase 1-F; UGT-1F; UGT1F; UDP-glucuronosyltransferase 1A6
Protein Family:UDP-glucuronosyltransferase
UniProt Gene Name:UGT1A6  
UniProt Entry Name:UD16_HUMAN
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