Epigenetics & Nuclear Signaling Antibodies 3
Anti-UBP1 Antibody (CAB4177)
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- SKU:
- CAB4177
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-UBP1 Antibody |
| Antibody SKU: | CAB4177 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 280-380 of human UBP1 (NP_055332.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HepG2, HeLa, MCF7, K-562 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 280-380 of human UBP1 (NP_055332.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IEDA VEHE QKKS SKRT LPAD YGDS LAKR GSCS PWPD APTA YVNN SPSP APTF TSPQ QSTC SVPD SNSS SPNH QGDG ASQT SGEQ IQPS ATIQ ETQQ WLLK N |
| Gene ID: | 7342 |
| Uniprot: | Q9NZI7 |
| Cellular Location: | Nucleus |
| Calculated MW: | 56kDa/60kDa |
| Observed MW: | 50kDa |
| Synonyms: | UBP1, LBP-1B, LBP-1a, LBP1A, LBP1B |
| Background: |
| UniProt Protein Function: | UBP1: Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. Belongs to the grh/CP2 family. CP2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 3p22.3 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:DNA binding; sequence-specific DNA binding; transcription factor activity; transcription corepressor activity Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral genome replication; angiogenesis; negative regulation of transcription, DNA-dependent |
| UniProt Code: | Q9NZI7 |
| NCBI GenInfo Identifier: | 74719655 |
| NCBI Gene ID: | |
| NCBI Accession: | Q9NZI7.1 |
| Molecular Weight: | 60kDa |
| NCBI Full Name: | Upstream-binding protein 1 |
| UniProt Protein Name: | Upstream-binding protein 1 |
| UniProt Synonym Protein Names: | Transcription factor LBP-1 |
| Protein Family: | UBP1-associated protein |
| UniProt Gene Name: | UBP1 |
| UniProt Entry Name: | UBIP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UBP1 antibody (CAB4177) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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