Cell Biology Antibodies 13
Anti-UBE4B Antibody (CAB17609)
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- SKU:
- CAB17609
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-UBE4B Antibody |
| Antibody SKU: | CAB17609 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-250 of human UBE4B (NP_006039.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Raji, OVCAR3, HeLa, Mouse testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-250 of human UBE4B (NP_006039.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EVDE NDRR EKRS LSDK EPSS GPEV SEEQ ALQL VCKI FRVS WKDR DRDV IFLS SLSA QFKQ NPKE VFSD FKDL IGQI LMEV LMMS TQTR DENP FASL TATS QPIA AAAR SPDR NLLL NTGS N |
| Gene ID: | 10277 |
| Uniprot: | O95155 |
| Cellular Location: | |
| Calculated MW: | 121kDa/133kDa/146kDa/151kDa |
| Observed MW: | 146kDa |
 | Western blot - UBE4B Polyclonal Antibody (CAB17609) |
| Synonyms: | E4, HDNB1, UBOX3, UFD2, UFD2A, UBE4B |
| Background: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | UBE4B: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3. Belongs to the ubiquitin conjugation factor E4 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ligase; EC 6.3.2.19; EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 1p36.3 Cellular Component: cytoplasm; nucleus; ubiquitin ligase complex Molecular Function:enzyme binding; ligase activity Biological Process: proteasomal ubiquitin-dependent protein catabolic process; induction of apoptosis by granzyme; protein ubiquitination during ubiquitin-dependent protein catabolic process; response to UV |
| NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95155 |
| NCBI GenInfo Identifier: | 24638295 |
| NCBI Gene ID: | 10277 |
| NCBI Accession: | O95155.1 |
| UniProt Related Accession: | O95155 |
| Molecular Weight: | |
| NCBI Full Name: | Ubiquitin conjugation factor E4 B |
| NCBI Synonym Full Names: | ubiquitination factor E4B |
| NCBI Official Symbol: | UBE4B |
| NCBI Official Synonym Symbols: | E4; UFD2; HDNB1; UBOX3; UFD2A |
| NCBI Protein Information: | ubiquitin conjugation factor E4 B |
| UniProt Protein Name: | Ubiquitin conjugation factor E4 B |
| UniProt Synonym Protein Names: | Homozygously deleted in neuroblastoma 1; Ubiquitin fusion degradation protein 2 |
| Protein Family: | Ubiquitin conjugation factor |
| UniProt Gene Name: | UBE4B |
| UniProt Entry Name: | UBE4B_HUMAN |
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