Anti-UBE4B Antibody (CAB0419)

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SKU:
CAB0419
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
E4
Synonyms:
HDNB1
Synonyms:
UBOX3
Synonyms:
UFD2
Synonyms:
UFD2A
Research Area:
Cell Biology

Description

Product Name:UBE4B Rabbit mAb
Product Code:CAB0419
Size:20uL, 50uL, 100uL
Synonyms:E4, HDNB1, UBOX3, UFD2, UFD2A
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human UBE4B.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:PC-12, SKOV3, NIH/3T3, K-562, Mouse liver, Mouse brain, Rat liver, Rat brain
Immunogen:A synthesized peptide derived from human UBE4B.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10277
Uniprot:O95155
Calculated MW:130kDa
Observed MW:146KDa
UniProt Protein Function:UBE4B: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3. Belongs to the ubiquitin conjugation factor E4 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ligase; EC 6.3.2.19; EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 1p36.3

Cellular Component: cytoplasm; nucleus; ubiquitin ligase complex

Molecular Function:enzyme binding; ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; induction of apoptosis by granzyme; protein ubiquitination during ubiquitin-dependent protein catabolic process; response to UV

NCBI Summary:The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O95155
NCBI GenInfo Identifier:24638295
NCBI Gene ID:10277
NCBI Accession:O95155.1
UniProt Related Accession:O95155
Molecular Weight:
NCBI Full Name:Ubiquitin conjugation factor E4 B
NCBI Synonym Full Names:ubiquitination factor E4B
NCBI Official Symbol:UBE4B  
NCBI Official Synonym Symbols:E4; UFD2; HDNB1; UBOX3; UFD2A  
NCBI Protein Information:ubiquitin conjugation factor E4 B
UniProt Protein Name:Ubiquitin conjugation factor E4 B
UniProt Synonym Protein Names:Homozygously deleted in neuroblastoma 1; Ubiquitin fusion degradation protein 2
Protein Family:Ubiquitin conjugation factor
UniProt Gene Name:UBE4B  
UniProt Entry Name:UBE4B_HUMAN
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