Cell Biology Antibodies 17

Thioredoxin reductase 1 (TXNRD1 ) Rabbit Monoclonal Antibody (CAB4725)

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SKU:
CAB4725
Product Type:
Antibody
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
Antibody Type:
Monoclonal Antibody
Reactivity:
Human, Mouse, Rat
Synonyms:
TR, TR1, TXNR, TRXR1, GRIM-12, Thioredoxin reductase 1 (TXNRD1 )
Research Use:
Cell Biology
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Description

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Thioredoxin reductase 1 (TXNRD1 ) Monoclonal Antibody (CAB4725)

The Thioredoxin reductase 1 (TXNRD1 ) Monoclonal Antibody (CAB4725) is a high-quality antibody developed for reliable detection and analysis of target proteins. The antibody, developed in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications.TXNRD1 is a crucial enzyme involved in maintaining cellular redox balance and protecting cells from oxidative stress. Dysregulation of TXNRD1 has been linked to various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.

Product Name:Thioredoxin reductase 1 (TXNRD1 ) Monoclonal Antibody
SKU:CAB4725
Size:20μL, 100μL
Reactivity:Human, Mouse, Rat
Clone Number:ARC1106
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:MGCA EGKA VAAA APTE LQTK GKNG DGRR RSAK DHHP GKTL PENP AGFT STAT ADSR ALLQ AYID GHSV VIFS RSTC TRCT EVKK LFKS LCVP YFVL ELDQ TEDG RALE GTLS ELAA ETDL PVVF VKQR KIGG HGPT LKAY QEGR LQKL LKMN GPED LPKS YDYD LIII GGGS GGLA AAKE AAQY GKKV MVLD FVTP TPLG TRWG LGGT CVNV GCIP KKLM HQAA LLGQ ALQD SRNY GWKV EETV KHDW DRMI EAVQ NHIG SLNW GYRV ALRE KKVV YENA YGQF IGPH RIKA TNNK GKEK IYSA ERFL IATG ERPR YLGI PGDK EYCI SSDD LFSL PYCP GKTL VVGA SYVA LECA GFLA GIGL DVTV MVRS ILLR GFDQ DMAN KIGE HMEE HGIK FIRQ FVPI KVEQ IEAG TPGR LRVV AQST NSEE IIEG EYNT VMLA IGRD ACTR KIGL ETVG VKIN EKTG KIPV TDEE QTNV PYIY AIGD ILED KVEL TPVA IQAG RLLA QRLY AGST VKCD YENV PTTV FTPL EYGA CGLS EEKA VEKF GEEN IEVY HSYF WPLE WTIP SRDN NKCY AKII CNTK DNER VVGF HVLG PNAG EVTQ GFAA ALKC GLTK KQLD STIG IHPV CAEV FTTL SVTK RSGA SILQ AGCU G
Tested Applications:WB ELISA
Recommended Dilution:
WB1:1000 - 1:4000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:TR, TR1, TXNR, TRXR1, GRIM-12, Thioredoxin reductase 1 (TXNRD1 )
Positive Sample:HeLa, A-549, MCF7, Jurkat, Mouse brain, Mouse heart, Mouse thymus, Rat liver, Rat kidney
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:71kDa
Observed MW:60kDa

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis.

Purification MethodAffinity purification
Gene ID7296
RRIDAB_2863332
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using Human Thioredoxin Reductase 1/TRXR1 Rabbit mAb (CAB4725) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
Product ImageWestern blot analysis of various lysates using Human Thioredoxin Reductase 1/TRXR1 Rabbit mAb (CAB4725) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s.
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