Developmental Biology

Anti-TSSK4 Antibody (CAB7861)

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SKU:
CAB7861
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-TSSK4 Antibody
Antibody SKU:CAB7861
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 79-328 of human TSSK4 (NP_777604.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 79-328 of human TSSK4 (NP_777604.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VLRH KYLI NFYR AIES TSRV YIIL ELAQ GGDV LEWI QRYG ACSE PLAG KWFS QLTL GIAY LHSK SIVH RDLK LENL LLDK WENV KISD FGFA KMVP SNQP VGCS PSYR QVNC FSHL SQTY CGSF AYAC PEIL RGLP YNPF LSDT WSMG VILY TLVV AHLP FDDT NLKK LLRE TQKE VTFP ANHT ISQE CKNL ILQM LRQA TKRA TILD IIKD SWVL KFQP EQPT HEIR LLEA MCQL HNTT KQHQ SLQI TT
Gene ID:283629
Uniprot:Q6SA08
Cellular Location:
Calculated MW:29kDa/37kDa/38kDa
Observed MW:37kDa
Synonyms:TSSK4, C14orf20, STK22E, TSK-4, TSK4, TSSK5
Background:This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:TSSK4: May be involved in a signaling pathway during male germ cell development or mature sperm function. Phosphorylates CREB1 on Ser-133 and stimulates downstream signaling. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.1; CAMK group; TSSK family

Chromosomal Location of Human Ortholog: 14q12

Cellular Component: cytoplasm; nucleus

Molecular Function:ATP binding; magnesium ion binding; protein binding; protein serine/threonine kinase activity

Biological Process: activation of CREB transcription factor; protein amino acid phosphorylation

NCBI Summary:This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Code:Q6SA08
NCBI GenInfo Identifier:62287888
NCBI Gene ID:283629
NCBI Accession:Q6SA08.1
UniProt Secondary Accession:Q6SA08,Q2TA60, Q6ZNM2,
UniProt Related Accession:Q6SA08
Molecular Weight:29,034 Da
NCBI Full Name:Testis-specific serine/threonine-protein kinase 4
NCBI Synonym Full Names:testis specific serine kinase 4
NCBI Official Symbol:TSSK4  
NCBI Official Synonym Symbols:TSK4; TSK-4; TSSK5; STK22E; C14orf20  
NCBI Protein Information:testis-specific serine/threonine-protein kinase 4
UniProt Protein Name:Testis-specific serine/threonine-protein kinase 4
UniProt Synonym Protein Names:Serine/threonine-protein kinase 22E
Protein Family:Testis-specific serine/threonine-protein kinase
UniProt Gene Name:TSSK4  
UniProt Entry Name:TSSK4_HUMAN
Anti-TSSK4 Antibody (CAB7861)Western blot analysis of extracts of mouse testis, using TSSK4 antibody (CAB7861) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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