Cell Biology Antibodies 4

Anti-TRPC1 Antibody (CAB14068)

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SKU:
CAB14068
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TRPC1 Antibody
Antibody SKU:CAB14068
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 400-500 of human TRPC1 (NP_001238774.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 400-500 of human TRPC1 (NP_001238774.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLNL YSLV YNED KKNT MGPA LERI DYLL ILWI IGMI WSDI KRLW YEGL EDFL EESR NQLS FVMN SLYL ATFA LKVV AHNK FHDF ADRK DWDA FHPT LVAE G
Gene ID:7220
Uniprot:P48995
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:87kDa/91kDa
Observed MW:Refer to figures
Synonyms:TRPC1, HTRP-1, TRP1
Background:The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:TRPC1: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q23

Cellular Component: integral to plasma membrane; plasma membrane; receptor complex

Molecular Function:calcium channel activity; cation channel activity; protein binding; store-operated calcium channel activity

Biological Process: calcium ion transport; cytosolic calcium ion homeostasis; manganese ion transport; melanin biosynthetic process; positive regulation of release of sequestered calcium ion into cytosol; response to calcium ion

NCBI Summary:The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
UniProt Code:P48995
NCBI GenInfo Identifier:1351302
NCBI Gene ID:7220
NCBI Accession:P48995.1
UniProt Secondary Accession:P48995,Q14CE4,
UniProt Related Accession:P48995
Molecular Weight:87,617 Da
NCBI Full Name:Short transient receptor potential channel 1
NCBI Synonym Full Names:transient receptor potential cation channel subfamily C member 1
NCBI Official Symbol:TRPC1  
NCBI Official Synonym Symbols:TRP1; HTRP-1  
NCBI Protein Information:short transient receptor potential channel 1
UniProt Protein Name:Short transient receptor potential channel 1
UniProt Synonym Protein Names:Transient receptor protein 1; TRP-1
Protein Family:Indole-3-glycerol phosphate synthase
UniProt Gene Name:TRPC1  
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