Cell Biology Antibodies 3
Anti-TRPC1 Antibody (CAB12525)
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- SKU:
- CAB12525
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TRPC1 Antibody |
| Antibody SKU: | CAB12525 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human TRPC1 (NP_001238774.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SW480, MCF7, SKOV3, Mouse kidney |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human TRPC1 (NP_001238774.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LLNL YSLV YNED KKNT MGPA LERI DYLL ILWI IGMI WSDI KRLW YEGL EDFL EESR NQLS FVMN SLYL ATFA LKVV AHNK FHDF ADRK DWDA FHPT LVAE G |
| Gene ID: | 7220 |
| Uniprot: | P48995 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 87kDa/91kDa |
| Observed MW: | 90kDa |
| Synonyms: | TRPC1, HTRP-1, TRP1 |
| Background: | The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | TRPC1: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3q23 Cellular Component: integral to plasma membrane; plasma membrane; receptor complex Molecular Function:calcium channel activity; cation channel activity; protein binding; store-operated calcium channel activity Biological Process: calcium ion transport; cytosolic calcium ion homeostasis; manganese ion transport; melanin biosynthetic process; positive regulation of release of sequestered calcium ion into cytosol; response to calcium ion |
| NCBI Summary: | The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | P48995 |
| NCBI GenInfo Identifier: | 1351302 |
| NCBI Gene ID: | 7220 |
| NCBI Accession: | P48995.1 |
| UniProt Secondary Accession: | P48995,Q14CE4, |
| UniProt Related Accession: | P48995 |
| Molecular Weight: | 87,617 Da |
| NCBI Full Name: | Short transient receptor potential channel 1 |
| NCBI Synonym Full Names: | transient receptor potential cation channel subfamily C member 1 |
| NCBI Official Symbol: | TRPC1 |
| NCBI Official Synonym Symbols: | TRP1; HTRP-1 |
| NCBI Protein Information: | short transient receptor potential channel 1 |
| UniProt Protein Name: | Short transient receptor potential channel 1 |
| UniProt Synonym Protein Names: | Transient receptor protein 1; TRP-1 |
| Protein Family: | Indole-3-glycerol phosphate synthase |
| UniProt Gene Name: | TRPC1 |
 | Western blot analysis of extracts of various cell lines, using TRPC1 antibody (CAB12525) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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