Developmental Biology

Anti-TRIP13 Antibody (CAB17357)

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SKU:
CAB17357
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Developmental Biology

Description

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Antibody Name:Anti-TRIP13 Antibody
Antibody SKU:CAB17357
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human TRIP13 (NP_004228.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, PC-3
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human TRIP13 (NP_004228.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:IgG
Sequence:MDEA VGDL KQAL PCVA ESPT VHVE VHQR GSST AKKE DINL SVRK LLNR HNIV FGDY TWTE FDEP FLTR NVQS VSII DTEL KVKD SQPI DLSA CTVA LHIF QLNE DGPS SENL EEET ENII
Gene ID:9319
Uniprot:Q15645
Cellular Location:
Calculated MW:22kDa/48kDa
Observed MW:48kDa
Synonyms:TRIP13, 16E1BP
Background:This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer.
UniProt Protein Function:TRIP13: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double- strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Belongs to the AAA ATPase family. PCH2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: nucleus

Molecular Function:identical protein binding; protein binding; transcription cofactor activity

Biological Process: double-strand break repair; meiotic recombination; oogenesis; spermatogenesis; synaptonemal complex assembly; transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]
UniProt Code:Q15645
NCBI GenInfo Identifier:85541056
NCBI Gene ID:9319
NCBI Accession:Q15645.2
UniProt Secondary Accession:Q15645,O15324, C9K0T3, D3DTC0,
UniProt Related Accession:Q15645
Molecular Weight:22,084 Da
NCBI Full Name:Pachytene checkpoint protein 2 homolog
NCBI Synonym Full Names:thyroid hormone receptor interactor 13
NCBI Official Symbol:TRIP13  
NCBI Official Synonym Symbols:16E1BP  
NCBI Protein Information:pachytene checkpoint protein 2 homolog
UniProt Protein Name:Pachytene checkpoint protein 2 homolog
UniProt Synonym Protein Names:Human papillomavirus type 16 E1 protein-binding protein; 16E1-BP; HPV16 E1 protein-binding protein; Thyroid hormone receptor interactor 13; Thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13
UniProt Gene Name:TRIP13  
UniProt Entry Name:PCH2_HUMAN
Anti-TRIP13 Antibody (CAB17357)Western blot analysis of extracts of various cell lines, using TRIP13 antibody (CAB17357) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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