Cell Cycle Antibodies 1

Anti-TRIOBP Antibody (CAB4485)

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SKU:
CAB4485
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
TRIOBP
Synonyms:
DFNB28
Synonyms:
HRIHFB2122
Synonyms:
TAP68
Synonyms:
TARA
Synonyms:
dJ37E16.4
Research Area:
Cell Cycle

Description

Product Name:TRIOBP Rabbit pAb
Product Code:CAB4485
Size:20uL, 50uL, 100uL
Synonyms:TRIOBP, DFNB28, HRIHFB2122, TAP68, TARA, dJ37E16.4
Applications:WB, IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 180-310 of human TRIOBP (NP_008963.3).
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:BxPC-3, U-87MG, HeLa, LO2, A-549, SW620, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 180-310 of human TRIOBP (NP_008963.3).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DVTK LSDS NKEN ALHS YSTQ KGPL KAGE QRAG SEVI SRGG PRKA DGQR QALD YVEL SPLT QASP QRAR TPAR TPDR LAKQ EELE RDLA QRSE ERRK WFEA TDSR TPEV PAGE GPRR GLGA PLTE DQQN RLS
Gene ID:11078
Uniprot:Q9H2D6
Cellular Location:Cytoplasm, Midbody, Nucleus, centrosome, cytoskeleton, cytoskeleton, microtubule organizing center
Calculated MW:47kDa/68kDa/74kDa/125kDa/243kDa/250kDa/261kDa
Observed MW:70kDa
UniProt Protein Function:Tara: May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. Defects in TRIOBP are the cause of deafness autosomal recessive type 28 (DFNB28). 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Actin-binding; Cytoskeletal

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: focal adhesion; cytoplasm; microtubule organizing center; midbody; nucleus; actin cytoskeleton

Molecular Function:actin filament binding; ubiquitin protein ligase binding; GTP-Rho binding; myosin II binding

Biological Process: mitosis; actin modification; cell division; barbed-end actin filament capping

Disease: Deafness, Autosomal Recessive 28

NCBI Summary:This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]
UniProt Code:Q9H2D6
NCBI GenInfo Identifier:90110075
NCBI Gene ID:11078
NCBI Accession:Q9H2D6.3
UniProt Secondary Accession:Q9H2D6,O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1 Q9BT77, B1AHD4, B1AHD7, F2Z2W0, F8W6V6,
UniProt Related Accession:Q9H2D6
Molecular Weight:2365
NCBI Full Name:TRIO and F-actin-binding protein
NCBI Synonym Full Names:TRIO and F-actin binding protein
NCBI Official Symbol:TRIOBP  
NCBI Official Synonym Symbols:TARA; TAP68; DFNB28; dJ37E16.4; HRIHFB2122  
NCBI Protein Information:TRIO and F-actin-binding protein; protein Tara; tara-like protein; trio-associated repeat on actin
UniProt Protein Name:TRIO and F-actin-binding protein
UniProt Synonym Protein Names:Protein Tara; Trio-associated repeat on actin
Protein Family:TRIO and F-actin-binding protein
UniProt Gene Name:TRIOBP  
UniProt Entry Name:TARA_HUMAN
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