Signal Transduction Antibodies 1
Anti-TRIM2 Antibody (CAB14393)
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- SKU:
- CAB14393
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-TRIM2 Antibody |
| Antibody SKU: | CAB14393 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human TRIM2 (NP_056086.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse small intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human TRIM2 (NP_056086.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GVAA LQNN FFIT NLMD VLQR TPGS NAEE SSIL ETVT AVAA GKPL SCPN HDGN VMEF YCQS CETA MCRE CTEG EHAE HPTV PLKD VVEQ HKAS LQVQ LDAV NKRL PEID SALQ FISE IIHQ LTNQ KASI VDDI HSTF DELQ KTLN VRKS VLLM ELEV NYGL KHKV LQSQ LDTL LQGQ ESIK SCSN FTAQ ALNH GTET EVLL V |
| Gene ID: | 23321 |
| Uniprot: | Q9C040 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 81kDa/84kDa |
| Observed MW: | 81kDa |
| Synonyms: | TRIM2, CMT2R, RNF86 |
| Background: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | TRIM2: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Belongs to the TRIM/RBCC family. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ubiquitin ligase; Ligase; EC 6.3.2.- Chromosomal Location of Human Ortholog: 4q31.3 Cellular Component: cytoplasm Molecular Function:protein binding; ubiquitin-protein ligase activity Biological Process: regulation of neuron apoptosis Disease: Charcot-marie-tooth Disease, Axonal, Type 2r |
| NCBI Summary: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] |
| UniProt Code: | Q9C040 |
| NCBI GenInfo Identifier: | 21363034 |
| NCBI Gene ID: | 23321 |
| NCBI Accession: | Q9C040.1 |
| UniProt Secondary Accession: | Q9C040,O60272, Q9BSI9, Q9UFZ1, D3DP09, |
| UniProt Related Accession: | Q9C040 |
| Molecular Weight: | 84,545 Da |
| NCBI Full Name: | Tripartite motif-containing protein 2 |
| NCBI Synonym Full Names: | tripartite motif containing 2 |
| NCBI Official Symbol: | TRIM2 |
| NCBI Official Synonym Symbols: | CMT2R; RNF86 |
| NCBI Protein Information: | tripartite motif-containing protein 2 |
| UniProt Protein Name: | Tripartite motif-containing protein 2 |
| UniProt Synonym Protein Names: | E3 ubiquitin-protein ligase TRIM2; RING finger protein 86 |
| Protein Family: | Tripartite motif-containing protein |
| UniProt Gene Name: | TRIM2 |
| UniProt Entry Name: | TRIM2_HUMAN |
 | Western blot analysis of extracts of mouse small intestine, using TRIM2 antibody (CAB14393) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
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