Developmental Biology
Anti-TRAPPC9 Antibody (CAB15527)
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- SKU:
- CAB15527
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-TRAPPC9 Antibody |
| Antibody SKU: | CAB15527 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 947-1246 of human TRAPPC9 (NP_113654.4). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 947-1246 of human TRAPPC9 (NP_113654.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SHVK TLEA VLNF KYSG GPGH TEGY YRNL SLGL HVEV EPSV FFTR VSTL PATS TRQC HLLL DVFN STEH ELTV STRS SEAL ILHA GECQ RMAI QVDK FNFE SFPE SPGE KGQF ANPK QLEE ERRE ARGL EIHS KLGI CWRI PSLK RSGE ASVE GLLN QLVL EHLQ LAPL QWDV LVDG QPCD REAV AACQ VGDP VRLE VRLT NRSP RSVG PFAL TVVP FQDH QNGV HNYD LHDT VSFV GSST FYLD AVQP SGQS ACLG ALLF LYTG DFFL HIRF HEDS TSKE LPPS WFCL PSVH VCAL EAQA |
| Gene ID: | 83696 |
| Uniprot: | Q96Q05 |
| Cellular Location: | Cytoplasm, Endoplasmic reticulum, Golgi apparatus, cis-Golgi network |
| Calculated MW: | 127kDa/128kDa/139kDa |
| Observed MW: | 150kDa |
| Synonyms: | TRAPPC9, IBP, IKBKBBP, MRT13, NIBP, T1, TRS120 |
| Background: | This gene encodes a protein that likely plays a role in NF-kappa-B signaling. Mutations in this gene have been associated with autosomal-recessive mental retardation. Alternatively spliced transcript variants have been described. |
| UniProt Protein Function: | NIBP: Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi. Defects in TRAPPC9 are the cause of mental retardation autosomal recessive type 13 (MRT13). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Brain magnetic resonance imaging of MRT13 patients indicates the presence of mild cerebral white matter hypoplasia. Microcephaly is present in some but not all affected individuals. Belongs to the NIBP family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Activator Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: Golgi apparatus; endoplasmic reticulum Biological Process: cell differentiation Disease: Mental Retardation, Autosomal Recessive 13 |
| NCBI Summary: | This gene encodes a protein that likely plays a role in NF-kappa-B signaling. Mutations in this gene have been associated with autosomal-recessive cognitive disability. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010] |
| UniProt Code: | Q96Q05 |
| NCBI GenInfo Identifier: | 190359999 |
| NCBI Gene ID: | 83696 |
| NCBI Accession: | Q96Q05.2 |
| UniProt Related Accession: | Q96Q05 |
| Molecular Weight: | 127kDa; 128kDa; 139kDa |
| NCBI Full Name: | Trafficking protein particle complex subunit 9 |
| NCBI Synonym Full Names: | trafficking protein particle complex 9 |
| NCBI Official Symbol: | TRAPPC9 |
| NCBI Official Synonym Symbols: | T1; IBP; NIBP; MRT13; TRS120; IKBKBBP |
| NCBI Protein Information: | trafficking protein particle complex subunit 9 |
| UniProt Protein Name: | Trafficking protein particle complex subunit 9 |
| UniProt Synonym Protein Names: | NIK- and IKBKB-binding protein; Tularik gene 1 protein |
| Protein Family: | Trafficking protein particle complex |
| UniProt Gene Name: | TRAPPC9 |
| UniProt Entry Name: | TPPC9_HUMAN |
 | Western blot analysis of extracts of mouse pancreas, using TRAPPC9 antibody (CAB15527) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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