Cell Biology Antibodies 18
Anti-TPX2 Antibody (CAB18327)
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- SKU:
- CAB18327
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TPX2 Antibody |
| Antibody SKU: | CAB18327 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TPX2. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: | A-549 |
| Immunogen: | Recombinant protein of human TPX2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 22974 |
| Uniprot: | Q9ULW0 |
| Cellular Location: | Cytoplasm, Nucleus, cytoskeleton, spindle, spindle pole |
| Calculated MW: | 85kDa |
| Observed MW: | 105KDa |
 | Western blot - TPX2 Rabbit pAb (CAB18327) |
| Synonyms: | DIL2, p100, DIL-2, HCTP4, FLS353, HCA519, REPP86, C20orf1, C20orf2, GD:C20orf1, TPX2 |
| Background: |
| UniProt Protein Function: | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940). |
| UniProt Code: | Q9ULW0 |
| NCBI GenInfo Identifier: | 13124096 |
| NCBI Gene ID: | 22974 |
| NCBI Accession: | Q9ULW0.2 |
| UniProt Secondary Accession: | Q9ULW0,Q96RR5, Q9H1R4, Q9NRA3, Q9UFN9, Q9UL00, Q9Y2M1 |
| UniProt Related Accession: | Q9ULW0 |
| Molecular Weight: | 89,393 Da |
| NCBI Full Name: | Targeting protein for Xklp2 |
| NCBI Synonym Full Names: | TPX2, microtubule nucleation factor |
| NCBI Official Symbol: | TPX2 |
| NCBI Official Synonym Symbols: | DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1 |
| NCBI Protein Information: | targeting protein for Xklp2 |
| UniProt Protein Name: | Targeting protein for Xklp2 |
| UniProt Synonym Protein Names: | Differentially expressed in cancerous and non-cancerous lung cells 2; DIL-2; Hepatocellular carcinoma-associated antigen 519; Hepatocellular carcinoma-associated antigen 90; Protein fls353; Restricted expression proliferation-associated protein 100; p100 |
| Protein Family: | Targeting protein |
| UniProt Gene Name: | TPX2 |
| UniProt Entry Name: | TPX2_HUMAN |
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