Cell Biology Antibodies 5

Anti-TOR1A Antibody (CAB15051)

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SKU:
CAB15051
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TOR1A Antibody
Antibody SKU:CAB15051
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human TOR1A (NP_000104.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, A-431, mouse brain, mouse kidney, mouse liver, mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human TOR1A (NP_000104.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PRLY CLFA ECCG QKRS LSRE ALQK DLDD NLFG QHLA KKII LNAV FGFI NNPK PKKP LTLS LHGW TGTG KNFV SKII AENI YEGG LNSD YVHL FVAT LHFP HASN ITLY KDQL QLWI RGNV SACA RSIF IFDE MDKM HAGL IDAI KPFL DYYD LVDG VSYQ KAMF IFLS NAGA ERIT DVAL DFWR SGKQ REDI KLKD IEHA LSVS VFNN KNSG FWHS SLID RNLI DYFV PFLP LEYK HLKM CIRV EMQS RGYE IDED IVSR V
Gene ID:1861
Uniprot:O14656
Cellular Location:Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoplasmic vesicle membrane, Endoplasmic reticulum lumen, Nucleus membrane, Peripheral membrane protein, cytoskeleton, growth cone, secretory vesicle, synaptic vesicle
Calculated MW:22kDa/37kDa
Observed MW:38kDa
Synonyms:TOR1A, DQ2, DYT1, torsin-1A
Background:The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1.
UniProt Protein Function:TOR1A: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and nesprin-3/C14orf49, leaving nuclear pores and SUN1 unchanged. May form homohexamers. Interacts with TOR1AIP1 and TOR1AIP2. Interacts with KLHL14, preferentially when ATP-free. Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord. Belongs to the clpA/clpB family. Torsin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: synaptic vesicle; transport vesicle; nuclear membrane; growth cone; cytoskeleton; cytoplasmic vesicle membrane; intracellular membrane-bound organelle; membrane; endoplasmic reticulum lumen; nuclear envelope; cell junction; secretory granule

Molecular Function:protein binding; kinesin binding; ATPase activity; cytoskeletal protein binding; unfolded protein binding; misfolded protein binding; ATP binding

Biological Process: protein deneddylation; chaperone cofactor-dependent protein folding; organelle organization and biogenesis; synaptic vesicle transport; regulation of dopamine uptake; intermediate filament cytoskeleton organization and biogenesis; response to oxidative stress; cell adhesion; nuclear membrane organization and biogenesis; neurite development; protein homooligomerization

Disease: Dystonia 1, Torsion, Autosomal Dominant

NCBI Summary:The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1. [provided by RefSeq, Jul 2008]
UniProt Code:O14656
NCBI GenInfo Identifier:13878817
NCBI Gene ID:1861
NCBI Accession:O14656.1
UniProt Secondary Accession:O14656,Q53Y64, Q96CA0, B2RB58,
UniProt Related Accession:O14656
Molecular Weight:37,809 Da
NCBI Full Name:Torsin-1A
NCBI Synonym Full Names:torsin family 1, member A (torsin A)
NCBI Official Symbol:TOR1A  
NCBI Official Synonym Symbols:DQ2; DYT1  
NCBI Protein Information:torsin-1A; torsin ATPase 1; torsin ATPase-1A; dystonia 1 protein; torsin family 1 member A; dystonia 1, torsion (autosomal dominant; torsin A)
UniProt Protein Name:Torsin-1A
UniProt Synonym Protein Names:Dystonia 1 protein; Torsin ATPase-1A (EC:3.6.4.-); Torsin family 1 member A
UniProt Gene Name:TOR1A  
UniProt Entry Name:TOR1A_HUMAN
Anti-TOR1A Antibody (CAB15051)Western blot analysis of extracts of various cell lines, using TOR1A antibody (CAB15051) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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