| UniProt Protein Function: | TOPORS: Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation. Interacts with PARK7/DJ-1. Interacts with TOP1. Interacts with p53/TP53; can both ubiquitinate and sumoylate p53/TP53. Interacts with the SUMO1 conjugating enzyme UBE2I. Interacts with SUMO1. Interacts with NKX3-1; polyubiquitinates NKX3-1 and induces its proteasomal degradation. Interacts with SIN3A; sumoylates SIN3A. Interacts with IKBKE; induced by DNA damage. By genotoxic agents such as cisplatin and camptothecin. Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression is commonly decreased in colon adenocarcinomas and lung cancers. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 6.3.2.19; EC 6.3.2.-; Ubiquitin conjugating system; Cell cycle regulation; Ligase; Ubiquitin ligase Cellular Component: centriole; spindle pole; PML body; nuclear speck; nucleus; photoreceptor connecting cilium; ubiquitin ligase complex; gamma-tubulin complex Molecular Function:protein binding; DNA binding; zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; metal ion binding; ribosomal S6-glutamic acid ligase activity; ubiquitin-protein ligase activity; coenzyme F420-0 gamma-glutamyl ligase activity; SUMO ligase activity; antigen binding; ligase activity Biological Process: ubiquitin-dependent protein catabolic process; protein monoubiquitination; proteasomal ubiquitin-dependent protein catabolic process; protein sumoylation; DNA damage response, signal transduction resulting in induction of apoptosis; positive regulation of ubiquitin-protein ligase activity; positive regulation of transcription, DNA-dependent; maintenance of protein localization in nucleus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; response to DNA damage stimulus; regulation of cell proliferation |
| UniProt Code: | Q80Z37 |
| NCBI GenInfo Identifier: | 29336062 |
| NCBI Gene ID: | 106021 |
| NCBI Accession: | NP_598858.2 |
| UniProt Secondary Accession: | Q80Z37,Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5 Q8CGC8, Q920L3, |
| UniProt Related Accession: | Q80Z37 |
| Molecular Weight: | 117,082 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase Topors |
| NCBI Synonym Full Names: | topoisomerase I binding, arginine/serine-rich |
| NCBI Official Symbol: | Topors |
| NCBI Official Synonym Symbols: | LUN; TP53BPL; AW105885; p53BP3/LUN |
| NCBI Protein Information: | E3 ubiquitin-protein ligase Topors; p53BP3; p53-binding protein 3; SUMO1-protein E3 ligase Topors; topoisomerase 1-binding RING finger; tumor suppressor p53-binding protein 3; topoisomerase I-binding RING finger protein; topoisomerase I-binding arginine/serine-rich protein |
| UniProt Protein Name: | E3 ubiquitin-protein ligase Topors |
| UniProt Synonym Protein Names: | SUMO1-protein E3 ligase Topors; Topoisomerase I-binding RING finger protein; Topoisomerase I-binding arginine/serine-rich protein; Tumor suppressor p53-binding protein 3; p53-binding protein 3; p53BP3 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | Topors |
| UniProt Entry Name: | TOPRS_MOUSE |
