KO Validated Antibodies 2

Anti-TOMM34 Antibody (CAB19960)[KO Validated]

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SKU:
CAB19960
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TOMM34 Antibody [KO Validated]
Antibody SKU:CAB19960
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human TOMM34.
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa
Immunogen:Recombinant protein of human TOMM34.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10953
Uniprot:Q15785
Cellular Location:Cytoplasm, Cytoplasmic side, Mitochondrion outer membrane, Peripheral membrane protein
Calculated MW:34kDa
Observed MW:34KDa
Anti-TOMM34 Antibody [KO Validated] (CAB19960)Western blot analysis of extracts from normal (control) and TOMM34 knockout (KO) HeLa cells, using TOMM34 antibody (CAB19960) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Synonyms:TOMM34, HTOM34P, TOM34, URCC3
Background:The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.
UniProt Protein Function:TOMM34: Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state. Belongs to the Tom34 family.
UniProt Protein Details:

Protein type:Chaperone; Mitochondrial

Chromosomal Location of Human Ortholog: -

Cellular Component: cytoplasm; integral to membrane; membrane; mitochondrial outer membrane; nucleoplasm; nucleus

Molecular Function:heat shock protein binding; protein binding

Biological Process: protein targeting to mitochondrion

NCBI Summary:The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]
UniProt Code:Q15785
NCBI GenInfo Identifier:24212065
NCBI Gene ID:10953
NCBI Accession:Q15785.2
UniProt Secondary Accession:Q15785,Q53GH9, Q6IBN7, Q9NTZ3,
UniProt Related Accession:Q15785
Molecular Weight:34,559 Da
NCBI Full Name:Mitochondrial import receptor subunit TOM34
NCBI Synonym Full Names:translocase of outer mitochondrial membrane 34
NCBI Official Symbol:TOMM34  
NCBI Official Synonym Symbols:TOM34; URCC3; HTOM34P  
NCBI Protein Information:mitochondrial import receptor subunit TOM34
UniProt Protein Name:Mitochondrial import receptor subunit TOM34
UniProt Synonym Protein Names:Translocase of outer membrane 34 kDa subunit
Protein Family:Mitochondrial import receptor
UniProt Gene Name:TOMM34  
UniProt Entry Name:TOM34_HUMAN
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