Cell Biology Antibodies 18
Anti-TNFSF4 Antibody (CAB18389)
- SKU:
- CAB18389
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TNFSF4 Antibody |
| Antibody SKU: | CAB18389 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human TNFSF4. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant protein of human TNFSF4. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7292 |
| Uniprot: | P23510 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | CD134L, CD252, GP34, OX-40L, OX4OL, TNLG2B, TXGP1, TNFSF4 |
| Background: |
| UniProt Protein Function: | TNFSF4: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance. Belongs to the tumor necrosis factor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell cycle regulation; Cytokine Chromosomal Location of Human Ortholog: 1q25 Cellular Component: extracellular space; cell surface; integral to plasma membrane Molecular Function:cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding Biological Process: negative regulation of T-helper 1 cell differentiation; positive regulation of interleukin-12 production; negative regulation of cytokine secretion; positive regulation of T cell cytokine production; defense response to nematode; signal transduction; positive regulation of activated T cell proliferation; positive regulation of interleukin-10 production; positive regulation of interleukin-4 production; T cell proliferation; regulation of adaptive immune response; positive regulation of T-helper 2 cell differentiation; negative regulation of regulatory T cell differentiation; negative regulation of interferon-gamma production; positive regulation of cell proliferation; positive regulation of interleukin-13 production; positive regulation of memory T cell differentiation; cholesterol metabolic process; positive regulation of T-helper 2 type immune response; response to virus; negative regulation of transcription factor activity; positive regulation of immunoglobulin mediated immune response; positive regulation of interleukin-6 production; positive regulation of CD4-positive, alpha beta T cell differentiation; positive regulation of immunoglobulin secretion; positive regulation of interferon-gamma production; negative regulation of interleukin-17 production; positive regulation of B cell activation; regulation of inflammatory response; positive regulation of interleukin-2 production; immune response; positive regulation of alpha-beta T cell proliferation; negative regulation of transcription, DNA-dependent; acute inflammatory response; positive regulation of inflammatory response Disease: Myocardial Infarction, Susceptibility To |
| NCBI Summary: | This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | P23510 |
| NCBI GenInfo Identifier: | 121540 |
| NCBI Gene ID: | 7292 |
| NCBI Accession: | P23510.1 |
| UniProt Secondary Accession: | P23510,Q5JZA5, Q8IV74, Q9HCN9, |
| UniProt Related Accession: | P23510 |
| Molecular Weight: | 15,427 Da |
| NCBI Full Name: | Tumor necrosis factor ligand superfamily member 4 |
| NCBI Synonym Full Names: | tumor necrosis factor (ligand) superfamily, member 4 |
| NCBI Official Symbol: | TNFSF4 |
| NCBI Official Synonym Symbols: | GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L |
| NCBI Protein Information: | tumor necrosis factor ligand superfamily member 4; CD134 ligand; glycoprotein Gp34; OX40 antigen ligand; tax-transcriptionally activated glycoprotein 1 (34kD) |
| UniProt Protein Name: | Tumor necrosis factor ligand superfamily member 4 |
| UniProt Synonym Protein Names: | Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD_antigen: CD252 |
| UniProt Gene Name: | TNFSF4 |
| UniProt Entry Name: | TNFL4_HUMAN |
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