Immunology Antibodies 2

Anti-TNFRSF21 Antibody (CAB7365)

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SKU:
CAB7365
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TNFRSF21 Antibody
Antibody SKU:CAB7365
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 371-655 of human TNFRSF21 (NP_055267.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, A-549, SW480, SW620, Mouse kidney, Mouse brain, Mouse lung, Rat brain, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 371-655 of human TNFRSF21 (NP_055267.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RKSS RTLK KGPR QDPS AIVE KAGL KKSM TPTQ NREK WIYY CNGH GIDI LKLV AAQV GSQW KDIY QFLC NASE REVA AFSN GYTA DHER AYAA LQHW TIRG PEAS LAQL ISAL RQHR RNDV VEKI RGLM EDTT QLET DKLA LPMS PSPL SPSP IPSP NAKL ENSA LLTV EPSP QDKN KGFF VDES EPLL RCDS TSSG SSAL SRNG SFIT KEKK DTVL RQVR LDPC DLQP IFDD MLHF LNPE ELRV IEEI PQAE DKLD RLFE IIGV KSQE ASQT LLDS VYSH LPDL L
Gene ID:27242
Uniprot:O75509
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:71kDa
Observed MW:110kDa
Synonyms:TNFRSF21, BM-018, CD358, DR6
Background:This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.
UniProt Protein Function:DR6: May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N- terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). Associates with TRADD. Interacts with N-APP. Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
UniProt Protein Details:

Protein type:Apoptosis; Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: axon; integral to plasma membrane; plasma membrane; intrinsic to plasma membrane

Molecular Function:protein binding

Biological Process: myelination; neuron apoptosis; adaptive immune response; negative regulation of T cell proliferation; negative regulation of myelination; apoptosis; regulation of oligodendrocyte differentiation; B cell apoptosis; negative regulation of B cell proliferation; cellular lipid metabolic process; T cell receptor signaling pathway; humoral immune response

NCBI Summary:This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]
UniProt Code:O75509
NCBI GenInfo Identifier:21264087
NCBI Gene ID:27242
NCBI Accession:O75509.1
UniProt Related Accession:O75509
Molecular Weight:Observed: 72 kDaPredicted: 72 kDa
NCBI Full Name:Tumor necrosis factor receptor superfamily member 21
NCBI Synonym Full Names:TNF receptor superfamily member 21
NCBI Official Symbol:TNFRSF21  
NCBI Official Synonym Symbols:DR6; CD358; BM-018  
NCBI Protein Information:tumor necrosis factor receptor superfamily member 21
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 21
UniProt Synonym Protein Names:Death receptor 6; CD_antigen: CD358
UniProt Gene Name:TNFRSF21  
UniProt Entry Name:TNR21_HUMAN
Anti-TNFRSF21 Antibody (CAB7365)Western blot analysis of extracts of various cell lines, using TNFRSF21 antibody (CAB7365) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 30s.
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system_update_altDatasheetHuman DR6/TNFRSF21 Recombinant Protein Tumor Necrosis Factor Receptor Superfamily Member 21 (TNFRSF21) is a type I transmembrane receptor that includes four extracellula