Cell Biology Antibodies 7

Anti-TMX1 Antibody (CAB17219)

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SKU:
CAB17219
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TMX1 Antibody
Antibody SKU:CAB17219
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 210-280 of human TMX1 (NP_110382.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 210-280 of human TMX1 (NP_110382.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KRRR PQPY PYPS KKLL SESA QPLK KVEE EQEA DEED VSEE EAES KEGT NKDF PQNA IRQR SLGP SLAT DKS
Gene ID:81542
Uniprot:Q9H3N1
Cellular Location:
Calculated MW:31kDa
Observed MW:Refer to figures
Synonyms:TMX1, PDIA11, TMX, TXNDC, TXNDC1
Background:This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides.
UniProt Protein Function:TXNDC1: May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q22.1

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; nucleolus

Molecular Function:disulfide oxidoreductase activity; protein disulfide isomerase activity

Biological Process: protein folding

NCBI Summary:TXNDC1 is a thioredoxin (TXN; see MIM 187700)-related protein with disulfide reductase activity (Matsuo et al., 2001 [PubMed 11152479]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9H3N1
NCBI GenInfo Identifier:47117631
NCBI Gene ID:81542
NCBI Accession:Q9H3N1.1
UniProt Secondary Accession:Q9H3N1,Q8N487, Q8NBN5, Q9Y4T6, B2R7A4,
UniProt Related Accession:Q9H3N1
Molecular Weight:31,791 Da
NCBI Full Name:Thioredoxin-related transmembrane protein 1
NCBI Synonym Full Names:thioredoxin related transmembrane protein 1
NCBI Official Symbol:TMX1  
NCBI Official Synonym Symbols:TMX; TXNDC; PDIA11; TXNDC1  
NCBI Protein Information:thioredoxin-related transmembrane protein 1
UniProt Protein Name:Thioredoxin-related transmembrane protein 1
UniProt Synonym Protein Names:Thioredoxin domain-containing protein 1; Transmembrane Trx-related protein
Protein Family:Thioredoxin-related transmembrane protein
UniProt Gene Name:TMX1  
UniProt Entry Name:TMX1_HUMAN
Anti-TMX1 Antibody (CAB17219)Western blot analysis of extracts of various cell lines, using TMX1 antibody (CAB17219) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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