Cell Biology Antibodies 5
Anti-TMX1 Antibody (CAB14936)
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- SKU:
- CAB14936
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-TMX1 Antibody |
| Antibody SKU: | CAB14936 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-280 of human TMX1 (NP_110382.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, LO2, HeLa, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-280 of human TMX1 (NP_110382.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KRRR PQPY PYPS KKLL SESA QPLK KVEE EQEA DEED VSEE EAES KEGT NKDF PQNA IRQR SLGP SLAT DKS |
| Gene ID: | 81542 |
| Uniprot: | Q9H3N1 |
| Cellular Location: | Endoplasmic reticulum membrane, Membrane, Single-pass type I membrane protein |
| Calculated MW: | 31kDa |
| Observed MW: | 35kDa |
| Synonyms: | TMX1, PDIA11, TMX, TXNDC, TXNDC1 |
| Background: | This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. |
| UniProt Protein Function: | TXNDC1: May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 14q22.1 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; nucleolus Molecular Function:disulfide oxidoreductase activity; protein disulfide isomerase activity Biological Process: protein folding |
| NCBI Summary: | TXNDC1 is a thioredoxin (TXN; see MIM 187700)-related protein with disulfide reductase activity (Matsuo et al., 2001 [PubMed 11152479]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9H3N1 |
| NCBI GenInfo Identifier: | 47117631 |
| NCBI Gene ID: | 81542 |
| NCBI Accession: | Q9H3N1.1 |
| UniProt Secondary Accession: | Q9H3N1,Q8N487, Q8NBN5, Q9Y4T6, B2R7A4, |
| UniProt Related Accession: | Q9H3N1 |
| Molecular Weight: | 31,791 Da |
| NCBI Full Name: | Thioredoxin-related transmembrane protein 1 |
| NCBI Synonym Full Names: | thioredoxin related transmembrane protein 1 |
| NCBI Official Symbol: | TMX1 |
| NCBI Official Synonym Symbols: | TMX; TXNDC; PDIA11; TXNDC1 |
| NCBI Protein Information: | thioredoxin-related transmembrane protein 1 |
| UniProt Protein Name: | Thioredoxin-related transmembrane protein 1 |
| UniProt Synonym Protein Names: | Thioredoxin domain-containing protein 1; Transmembrane Trx-related protein |
| Protein Family: | Thioredoxin-related transmembrane protein |
| UniProt Gene Name: | TMX1 |
| UniProt Entry Name: | TMX1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TMX1 antibody (CAB14936) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded rat brain using TMX1 antibody (CAB14936) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat spleen using TMX1 antibody (CAB14936) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using TMX1 antibody (CAB14936) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using TMX1 antibody (CAB14936) at dilution of 1:100 (40x lens). |
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