Cell Biology Antibodies 17

Anti-TMPRSS2 Antibody (CAB9126)

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SKU:
CAB9126
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-TMPRSS2 Antibody
Antibody SKU:CAB9126
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human TMPRSS2
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, A-549, PC-3, Mouse kidney, Mouse stomach, Rat kidney
Immunogen:A synthesized peptide derived from human TMPRSS2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7113
Uniprot:O15393
Cellular Location:
Calculated MW:54kDa
Observed MW:52KDa
Synonyms:PP9284, PRSS10
Background:This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
UniProt Protein Function:TMPRSS2: a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
UniProt Protein Details:

Protein type:EC 3.4.21.-; Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:protein binding; serine-type peptidase activity

Biological Process: positive regulation of virion penetration into host cell; protein autoprocessing; proteolysis

NCBI Summary:This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
UniProt Code:O15393
NCBI GenInfo Identifier:115502469
NCBI Gene ID:7113
NCBI Accession:O15393.3
UniProt Secondary Accession:O15393,Q6GTK7, Q9BXX1, A8K6Z8, B2R8E5, B7Z459, D3DSJ2 F8WES1,
UniProt Related Accession:O15393
Molecular Weight:57,690 Da
NCBI Full Name:Transmembrane protease serine 2
NCBI Synonym Full Names:transmembrane protease, serine 2
NCBI Official Symbol:TMPRSS2  
NCBI Official Synonym Symbols:PP9284; PRSS10  
NCBI Protein Information:transmembrane protease serine 2
UniProt Protein Name:Transmembrane protease serine 2
UniProt Synonym Protein Names:Serine protease 10
Protein Family:Transmembrane protease serine
UniProt Gene Name:TMPRSS2  
UniProt Entry Name:TMPS2_HUMAN
Anti-TMPRSS2 Antibody (CAB9126)Western blot - TMPRSS2 Rabbit mAb (CAB9126)
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