Antibody Name:	Anti-TMEM43 Antibody
Antibody SKU:	CAB8509
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 80-310 of human TMEM43 (NP_077310.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:	Human, Mouse
Positive Samples:	SKOV3, SW620, MCF7, Mouse kidney

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 80-310 of human TMEM43 (NP_077310.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	VAPE NEGR LVHI IGAL RTSK LLSD PNYG VHLP AVKL RRHV EMYQ WVET EESR EYTE DGQV KKET RYSY NTEW RSEI INSK NFDR EIGH KNPS AMAV ESFM ATAP FVQI GRFF LSSG LIDK VDNF KSLS LSKL EDPH VDII RRGD FFYH SENP KYPE VGDL RVSF SYAG LSGD DPDL GPAH VVTV IARQ RGDQ LVPF STKS GDTL LLLH HGDF SAEE VFHR ELRS NSMK TWG
Gene ID:	79188
Uniprot:	Q9BTV4
Cellular Location:	Endoplasmic reticulum, Multi-pass membrane protein, Nucleus inner membrane
Calculated MW:	44kDa
Observed MW:	45kDa

Synonyms:

TMEM43, ARVC5, ARVD5, EDMD7, LUMA

Background:

This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC.

UniProt Protein Function:	TMEM43: May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane. Defects in TMEM43 are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5); also known as arrhythmogenic right ventricular cardiomyopathy (ARVC5). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Belongs to the TMEM43 family.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 3p25.1 Cellular Component: Golgi apparatus Molecular Function:protein binding Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 5; Emery-dreifuss Muscular Dystrophy 7, Autosomal Dominant
NCBI Summary:	This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC. [provided by RefSeq, Oct 2008]
UniProt Code:	Q9BTV4
NCBI GenInfo Identifier:	74733151
NCBI Gene ID:	79188
NCBI Accession:	Q9BTV4.1
UniProt Secondary Accession:	Q9BTV4,Q7L4N5, Q8NC30, Q96A63, Q96F19, Q96JX0, Q9H076
UniProt Related Accession:	Q9BTV4
Molecular Weight:	44,876 Da
NCBI Full Name:	Transmembrane protein 43
NCBI Synonym Full Names:	transmembrane protein 43
NCBI Official Symbol:	TMEM43
NCBI Official Synonym Symbols:	LUMA; ARVC5; ARVD5; EDMD7
NCBI Protein Information:	transmembrane protein 43
UniProt Protein Name:	Transmembrane protein 43
UniProt Synonym Protein Names:	Protein LUMA
Protein Family:	Transmembrane protein
UniProt Gene Name:	TMEM43
UniProt Entry Name:	TMM43_HUMAN

	Western blot analysis of extracts of various cell lines, using TMEM43 antibody (CAB8509) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5s.
	Immunohistochemistry of paraffin-embedded human stomach using TMEM43 antibody (CAB8509) at dilution of 1:100 (40x lens).